| WBGene00001159 | SMap | S_parent | Sequence | C26D10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | eff-1 | Person_evidence | WBPerson689 |
| | | Sequence_name | C26D10.5 |
| | | Molecular_name | C26D10.5a |
| | | | C26D10.5a.1 |
| | | | CE03028 |
| | | | C26D10.5b |
| | | | CE30881 |
| | | | C26D10.5b.1 |
| | | | C26D10.5c |
| | | Other_name | elf-1 | Paper_evidence | WBPaper00004116 |
| | | | | Person_evidence | WBPerson493 |
| | | | CELE_C26D10.5 | Accession_evidence | NDB | BX284602 |
| | | Public_name | eff-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | eff |
| | Allele (65) |
| | Legacy_information | BP75: Temperature sensitive. Cell fusion-defective embryos, larvae and adults at 25C. Cell fusion defects are less penetrant at 15C. Egl, Unv, Pvl, Dpy and 2% Muv at 20C and 25C. Mutants have body morphological defects and bulged tails at all temperatures, male tails are leptoderan. Partial sterility of hermaphrodites: brood size is 48 at 25C. sd-4%. ME=0. ES=3. OA-1 (oj55: complete embryonic and partial post-embryonic epithelial fusion failure). Cloned: encodes a type-I membrane glycoprotein with a single TM domain. |
| | Strain (15) |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Ortholog (34) |
| | Paralog | WBGene00016625 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00023420 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | eff-1 encodes novel, nematode-specific type I transmembrane and secreted glycoproteins; during development, EFF-1 functions as a fusogen required, in both fusion partners, for the initiation and expansion of membrane mergers that characterize cell fusions; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure; eff-1::GFP reporter fusions are expressed in the epidermis, pharynx, and uterus, as well as in some neurons; when expressed in tissue culture cells, the EFF-1A and EFF-1B isoforms are detected on the plasma membrane, while the EFF-1C isoform is found to be partially secreted. | Paper_evidence | WBPaper00005122 |
| | | | | | WBPaper00024363 |
| | | | | | WBPaper00025022 |
| | | | | | WBPaper00028553 |
| | | | | | WBPaper00029040 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 14 Sep 2007 00:00:00 |
| | | Automated_description | Enables fusogenic activity and identical protein binding activity. Involved in several processes, including anatomical structure morphogenesis; egg-laying behavior; and pharyngeal muscle development. Located in cell-cell contact zone; cytoplasm; and plasma membrane. Expressed in several structures, including P3.pa; P3.pp; hypodermis; tail spike; and vulval cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C26D10.5a |
| | | C26D10.5b |
| | Corresponding_CDS_history | C26D10.5:wp80 |
| | | C26D10.5c:wp252 |
| | | C26D10.5d:wp252 |
| | Corresponding_transcript | C26D10.5c |
| | | C26D10.5a.1 |
| | | C26D10.5b.1 |
| | Other_sequence | JI169687.1 |
| | | Acan_isotig23020 |
| | | Dviv_isotig20177 |
| | | Dviv_isotig30648 |
| | | ACC41070_1 |
| | | EX544342.1 |
| | Associated_feature (17) |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern (17) |
| | Drives_construct (11) |
| | Construct_product | WBCnstr00005228 |
| | | WBCnstr00011238 |
| | | WBCnstr00012513 |
| | | WBCnstr00013131 |
| | | WBCnstr00015968 |
| | | WBCnstr00015970 |
| | | WBCnstr00022778 |
| | | WBCnstr00037057 |
| | | WBCnstr00040695 |
| | | WBCnstr00041861 |
| | Antibody | WBAntibody00002681 |
| | Microarray_results (35) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00041071:spe-44_downregulated |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00043945:MeHg_upregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045420:fertilization_upregulated_transcript |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00048690:gonad-male-biased |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049635:dop-1(vs100)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:mir-71(n4115)_upregulated_mRNA |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057265:metaformin_downregulated_OP50-MR |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060703:nas-38(ok3407)_upregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:HB115_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Excretory_gland |
| | | WBPaper00061340:hyp4_hyp5_hyp6 |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:tnt-4-myo-1_2160 |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_downregulated_germline |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065272:dhgd-1(tm6671)_upregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:50_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_23 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00044535:male_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_B |
| | Interaction (48) |
| Map_info | Map | II | Position | 0.76404 | Error | 0.00098 |
| | Positive | Positive_clone | C26D10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4274 |
| | | | 4399 |
| | | | 4902 |
| | Pseudo_map_position |
| Reference (144) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
