WormBase Tree Display for Gene: WBGene00001006

WBGene00001006 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C25F6
  Identity: Version: 1
    Name: CGC_name: dlg-1
      Sequence_name: C25F6.2
      Molecular_name: C25F6.2
        C25F6.2.1
        CE36524
      Other_name: CELE_C25F6.2 Accession_evidence: NDB BX284606
      Public_name: dlg-1
    DB_info: Database: AceView gene XG103
        WormQTL gene WBGene00001006
        WormFlux gene WBGene00001006
        NDB locus_tag CELE_C25F6.2
        Panther gene CAEEL|WormBase=WBGene00001006|UniProtKB=G5ECY0
          family PTHR23119
        NCBI gene 180819
        RefSeq protein NM_001029260.5
        SwissProt UniProtAcc G5ECY0
        UniProt_GCRP UniProtAcc G5ECY0
        OMIM gene 300189
            602887
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dlg
    Allele (112)
    Possibly_affected_by: WBVar02153212
    Strain: WBStrain00007529
      WBStrain00033917
      WBStrain00024324
      WBStrain00026592
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog (51)
    Paralog: WBGene00011890 Caenorhabditis elegans From_analysis: Panther
      WBGene00017741 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: dlg-1 encodes a MAGUK protein, orthologous to Drosophila Discs large; DLG-1 is physically located at apical adherens junctions in all epithelia and is required for organization of the embryonic gut epithelium into a coherent tube. Paper_evidence: WBPaper00004424
            WBPaper00004510
            WBPaper00006400
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 27 Jan 2012 00:00:00
      Automated_description: Predicted to enable guanylate kinase activity. Involved in embryo development and zonula adherens assembly. Located in adherens junction and apical junction complex. Expressed in several structures, including arcade cell; germ line; intestine; pharyngeal cell; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; cervix uteri carcinoma in situ; intellectual disability (multiple); and invasive ductal carcinoma. Is an ortholog of human DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2903)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2903)
      DOID:8991 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2900)
      DOID:3008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2900)
      DOID:0112041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2902)
  Molecular_info: Corresponding_CDS: C25F6.2
    Corresponding_CDS_history: C25F6.2a:wp121
      C25F6.2b:wp271
    Corresponding_transcript: C25F6.2.1
    Other_sequence (86)
    Associated_feature (29)
  Experimental_info: RNAi_result (34)
    Expr_pattern (15)
    Drives_construct (17)
    Construct_product: WBCnstr00000944
      WBCnstr00006155
      WBCnstr00007873
      WBCnstr00010311
      WBCnstr00010468
      WBCnstr00015686
      WBCnstr00020203
      WBCnstr00020897
      WBCnstr00037145
      WBCnstr00042006
    Antibody: WBAntibody00000342
      WBAntibody00000426
      WBAntibody00000715
      WBAntibody00000716
      WBAntibody00000993
      WBAntibody00001401
      WBAntibody00001716
      WBAntibody00001732
      WBAntibody00002172
      WBAntibody00002424
    Microarray_results (27)
    Expression_cluster: WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044760:somatic_specific
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:F_U
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:Glia
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:K_Kprime
      WBPaper00061340:mc3
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:P_cell
      WBPaper00061340:T
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
      WBPaper00065841:5_1
      WBPaper00065841:11_2
      WBPaper00065841:56_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_3
      cgc4489_group_24
      WBPaper00005475:Aging-regulated
      WBPaper00025032:cluster_129
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00029437:rde-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045673:colistin_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00050767:Octopamine_induced
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_12
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (1194)
  Map_info: Map: X Position: -5.25173 Error: 0.010511
    Positive: Positive_clone: C25F6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4261
        4449
    Pseudo_map_position
  Reference (97)
  Remark: Sequence connection from [Bossinger O]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene