WormBase Tree Display for Gene: WBGene00000912
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| WBGene00000912 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | daf-16 | Person_evidence | WBPerson521 | |||||
| Sequence_name | R13H8.1 | ||||||||
| Molecular_name (33) | |||||||||
| Other_name | daf-17 | ||||||||
| CELE_R13H8.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | daf-16 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 23 May 2013 11:00:05 | WBPerson2970 | Event | Acquires_merge | WBGene00043474 | ||||
| Acquires_merge | WBGene00043474 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | daf | ||||||||
| Reference_allele | WBVar00088538 | ||||||||
| Allele (348) | |||||||||
| Possibly_affected_by | WBVar02158491 | ||||||||
| WBVar02158841 | |||||||||
| WBVar02158939 | |||||||||
| Legacy_information | m26 : defective dauer formation (daf-4 suppressible). ES1. ME3. NA1. | ||||||||
| m27 : defective dauer formation (daf-14 suppressible). ES1 ME3. NA5. | |||||||||
| [C.elegansII] m26 : defective dauer formation. Suppresses Age phenotype of age-1, daf-2. ES1. ME3. OA>10: m27 (pka daf-17), mg11 (possible defect in maintenance of dauer state). [Gottlieb and Ruvkun 1994; DR; GR] | |||||||||
| Strain (110) | |||||||||
| Component_of_genotype | WBGenotype00000130 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00000661 | ||||||||
| 00000662 | |||||||||
| 00000663 | |||||||||
| 00000664 | |||||||||
| 00000665 | |||||||||
| 00000666 | |||||||||
| 00028667 | |||||||||
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| 00028805 | |||||||||
| 00108004 | |||||||||
| 00108005 | |||||||||
| 00108006 | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00001434 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00001438 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001440 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001441 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001442 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00002601 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003017 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003976 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004013 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006853 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function. | Paper_evidence (15) | ||||||
| Person_evidence | WBPerson4498 | ||||||||
| WBPerson12101 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson48 | |||||||||
| WBPerson567 | |||||||||
| WBPerson363 | |||||||||
| Date_last_updated | 28 Oct 2015 00:00:00 | ||||||||
| Automated_description | Enables several functions, including 14-3-3 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including defense response to other organism; regulation of dauer larval development; and regulation of gene expression. Located in cytosol and nucleus. Expressed in several structures, including germ cell; gonad; hypodermis; neurons; and somatic cell. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alveolar rhabdomyosarcoma; reproductive organ cancer (multiple); and rheumatoid arthritis. Is an ortholog of human FOXO4 (forkhead box O4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2022 00:00:00 | ||||||||
| DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 27 Jan 2015 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | |||||
| DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||||
| DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819,HGNC:3821) | ||||||
| DOID:4051 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||||
| DOID:2870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||||
| DOID:3328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||||
| Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||||
| WBPaper00025083 | |||||||||
| WBPaper00031384 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 27 Jan 2015 00:00:00 | ||||||||
| In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||||
| Modifies_disease | DOID:332 | ||||||||
| Models_disease_in_annotation | WBDOannot00000340 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001226 | ||||||||
| Models_disease_asserted | WBDOannot00001357 | ||||||||
| Molecular_info | Corresponding_CDS (11) | ||||||||
| Corresponding_CDS_history | R13H8.1d:wp144 | ||||||||
| R13H8.1f:wp214 | |||||||||
| R13H8.1g:wp274 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature (54) | |||||||||
| Gene_product_binds (13568) | |||||||||
| Transcription_factor | WBTranscriptionFactor000025 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | I | Position | 5.08393 | Error | 0.026229 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mgDf50 | |||||||
| Positive_clone | F55A3 | Author_evidence | Ogg SC | ||||||
| R13H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 441 | |||||||
| 442 | |||||||||
| Multi_point | 335 | ||||||||
| 336 | |||||||||
| 2218 | |||||||||
| 3631 | |||||||||
| 3703 | |||||||||
| 3886 | |||||||||
| 4480 | |||||||||
| 4913 | |||||||||
| Reference (1993) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| WBPicture0000013087 | |||||||||
| Remark | Related to forkhead/HNF-3 family of winged helix transcription factors [Ogg S] | ||||||||
| R13H8.1 must be sequence since it is also forkhead. sdm 141100 | |||||||||
| Method | Gene |
