WormBase Tree Display for Gene: WBGene00001434
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| WBGene00001434 | SMap | S_parent | Sequence | T14G12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fkh-2 | Person_evidence | WBPerson411 | |||||
| Sequence_name | T14G12.4 | ||||||||
| Molecular_name | T14G12.4a | ||||||||
| T14G12.4a.1 | |||||||||
| CE04965 | |||||||||
| T14G12.4b | |||||||||
| CE29342 | |||||||||
| T14G12.4b.1 | |||||||||
| Other_name | CELE_T14G12.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | fkh-2 | ||||||||
| DB_info | Database | AceView | gene | XE360 | |||||
| WormQTL | gene | WBGene00001434 | |||||||
| WormFlux | gene | WBGene00001434 | |||||||
| NDB | locus_tag | CELE_T14G12.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001434|UniProtKB=Q22510 | |||||||
| family | PTHR11829 | ||||||||
| NCBI | gene | 180663 | |||||||
| RefSeq | protein | NM_076243.9 | |||||||
| NM_001392750.1 | |||||||||
| SwissProt | UniProtAcc | Q22510 | |||||||
| UniProt_GCRP | UniProtAcc | Q22510 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fkh | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00031566 | ||||||||
| WBStrain00055341 | |||||||||
| Component_of_genotype | WBGenotype00000145 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00003017 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003976 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004013 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001438 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001440 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001441 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001442 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002601 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006853 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | fkh-2 encodes one of 15 C. elegans forkhead transcription factors and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); fkh-2 is required, along with ceh-37, for proper development of the AWB chemosensory neurons; specifically, fkh-2 is required for development of AWB-specific ciliary and dendritic structures and for positive regulation of expression of genes such as str-1, odr-1, and kap-1; in addition, although loss of fkh-2 activity via RNA-mediated interference (RNAi) results in only mild locomotion defects in L1 larvae, loss of both fkh-2 and pes-1, which also encodes a forkhead transcription factor, results in embryonic and larval lethality; fkh-2 is expressed broadly in embryos in descendants of the D and AB founder cell lineages; postembryonically, FKH-2 is expressed in AWB, and other, chemosensory neurons; fkh-2 expression in AWB is positively regulated by the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00004461 | |||||
| WBPaper00005730 | |||||||||
| WBPaper00029400 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Nov 2009 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly. Located in nucleus. Expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Is an ortholog of human FOXG1 (forkhead box G1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Modifies_disease | DOID:1440 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001320 | ||||||||
| Molecular_info | Corresponding_CDS | T14G12.4a | |||||||
| T14G12.4b | |||||||||
| Corresponding_transcript | T14G12.4a.1 | ||||||||
| T14G12.4b.1 | |||||||||
| Other_sequence | Dviv_isotig32092 | ||||||||
| JI177266.1 | |||||||||
| Oden_isotig25520 | |||||||||
| Associated_feature | WBsf653862 | ||||||||
| WBsf670009 | |||||||||
| WBsf670358 | |||||||||
| WBsf978547 | |||||||||
| WBsf1004702 | |||||||||
| WBsf1004703 | |||||||||
| WBsf1004704 | |||||||||
| WBsf1022665 | |||||||||
| WBsf1022666 | |||||||||
| Gene_product_binds (123) | |||||||||
| Transcription_factor | WBTranscriptionFactor000165 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00018725 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075637 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035579 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075636 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053342 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075638 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1472 | ||||||||
| Expr4692 | |||||||||
| Expr7317 | |||||||||
| Expr7666 | |||||||||
| Expr1013859 | |||||||||
| Expr1030859 | |||||||||
| Expr1156928 | |||||||||
| Expr1200044 | |||||||||
| Expr2011804 | |||||||||
| Expr2030042 | |||||||||
| Drives_construct | WBCnstr00000637 | ||||||||
| WBCnstr00012527 | |||||||||
| WBCnstr00012811 | |||||||||
| WBCnstr00036952 | |||||||||
| Construct_product | WBCnstr00016700 | ||||||||
| WBCnstr00036952 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (58) | |||||||||
| Map_info | Map | X | Position | -9.50037 | Error | 0.044105 | |||
| Positive | Positive_clone | T14G12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4310 | |||||||
| 4291 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
