WormBase Tree Display for Gene: WBGene00001434
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WBGene00001434 | SMap | S_parent | Sequence | T14G12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fkh | ||||||
Allele (30) | |||||||
Strain | WBStrain00031566 | ||||||
WBStrain00055341 | |||||||
Component_of_genotype | WBGenotype00000145 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (45) | |||||||
Paralog | WBGene00003017 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003976 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004013 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001438 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001440 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001441 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001442 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00002601 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00006853 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | fkh-2 encodes one of 15 C. elegans forkhead transcription factors and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); fkh-2 is required, along with ceh-37, for proper development of the AWB chemosensory neurons; specifically, fkh-2 is required for development of AWB-specific ciliary and dendritic structures and for positive regulation of expression of genes such as str-1, odr-1, and kap-1; in addition, although loss of fkh-2 activity via RNA-mediated interference (RNAi) results in only mild locomotion defects in L1 larvae, loss of both fkh-2 and pes-1, which also encodes a forkhead transcription factor, results in embryonic and larval lethality; fkh-2 is expressed broadly in embryos in descendants of the D and AB founder cell lineages; postembryonically, FKH-2 is expressed in AWB, and other, chemosensory neurons; fkh-2 expression in AWB is positively regulated by the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00004461 | |||
WBPaper00005730 | |||||||
WBPaper00029400 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 11 Nov 2009 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly. Located in nucleus. Expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Is an ortholog of human FOXG1 (forkhead box G1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Modifies_disease | DOID:1440 | ||||||
Modifies_disease_in_annotation | WBDOannot00001320 | ||||||
Molecular_info | Corresponding_CDS | T14G12.4a | |||||
T14G12.4b | |||||||
Corresponding_transcript | T14G12.4a.1 | ||||||
T14G12.4b.1 | |||||||
Other_sequence | Dviv_isotig32092 | ||||||
JI177266.1 | |||||||
Oden_isotig25520 | |||||||
Associated_feature | WBsf653862 | ||||||
WBsf670009 | |||||||
WBsf670358 | |||||||
WBsf978547 | |||||||
WBsf1004702 | |||||||
WBsf1004703 | |||||||
WBsf1004704 | |||||||
WBsf1022665 | |||||||
WBsf1022666 | |||||||
Gene_product_binds (123) | |||||||
Transcription_factor | WBTranscriptionFactor000165 | ||||||
Experimental_info | RNAi_result | WBRNAi00018725 | Inferred_automatically | RNAi_primary | |||
WBRNAi00075637 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00113574 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00035579 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075636 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053342 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075638 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1472 | ||||||
Expr4692 | |||||||
Expr7317 | |||||||
Expr7666 | |||||||
Expr1013859 | |||||||
Expr1030859 | |||||||
Expr1156928 | |||||||
Expr1200044 | |||||||
Expr2011804 | |||||||
Expr2030042 | |||||||
Drives_construct | WBCnstr00000637 | ||||||
WBCnstr00012527 | |||||||
WBCnstr00012811 | |||||||
WBCnstr00036952 | |||||||
Construct_product | WBCnstr00016700 | ||||||
WBCnstr00036952 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (131) | |||||||
Interaction (58) | |||||||
Map_info | Map | X | Position | -9.50037 | Error | 0.044105 | |
Positive | Positive_clone | T14G12 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4310 | |||||
4291 | |||||||
Pseudo_map_position | |||||||
Reference (19) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |