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WormBase Tree Display for Gene: WBGene00001440

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Name Class

WBGene00001440SMapS_parentSequenceF40H3
IdentityVersion1
NameCGC_namefkh-8Person_evidenceWBPerson411
Sequence_nameF40H3.4
Molecular_nameF40H3.4
F40H3.4.1
CE46821
Other_nameCELE_F40H3.4Accession_evidenceNDBBX284602
Public_namefkh-8
DB_infoDatabaseAceViewgene2G480
WormQTLgeneWBGene00001440
WormFluxgeneWBGene00001440
NDBlocus_tagCELE_F40H3.4
PanthergeneCAEEL|WormBase=WBGene00001440|UniProtKB=H2KZ39
familyPTHR11829
NCBIgene174026
RefSeqproteinNM_001267178.4
TrEMBLUniProtAccH2KZ39
UniProt_GCRPUniProtAccH2KZ39
OMIMgene602402
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfkh
Allele (24)
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (37)
ParalogWBGene00001434Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001438Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003017Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003976Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004013Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002601Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006853Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001442Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001441Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000912Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionfkh-8 encodes one of 15 C. elegans forkhead transcription factors; loss of fkh-8 activity via RNAi has been reported to result in either no defects or a weakly penetrant aldicarb resistance phenotype; an FKH-8 reporter fusion is expressed in nerve cells in the head and tail ganglia of both males and hermaphrodites with expression beginning in the later stages of embryogenesis and continuing through adulthood.Paper_evidenceWBPaper00005730
WBPaper00026667
Curator_confirmedWBPerson1843
Date_last_updated17 Nov 2006 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ASEL; ASER; head neurons; neurons; and tail neurons. Human ortholog(s) of this gene implicated in several diseases, including lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is an ortholog of human FOXC2 (forkhead box C2); FOXL3 (forkhead box L3); and FOXL3-OT1.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:530Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:0111509Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:4977Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:9970Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:10952Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
DOID:0060260Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3801)
Molecular_infoCorresponding_CDSF40H3.4
Corresponding_CDS_historyF40H3.4a:wp274
Corresponding_transcriptF40H3.4.1
Associated_featureWBsf650116
WBsf650117
WBsf665241
WBsf988093
WBsf988094
WBsf1012342
WBsf1012343
WBsf223134
Transcription_factorWBTranscriptionFactor000171
Experimental_infoRNAi_resultWBRNAi00113576Inferred_automaticallyRNAi_primary
WBRNAi00060919Inferred_automaticallyRNAi_primary
WBRNAi00095107Inferred_automaticallyRNAi_primary
WBRNAi00046920Inferred_automaticallyRNAi_primary
WBRNAi00060920Inferred_automaticallyRNAi_primary
WBRNAi00060917Inferred_automaticallyRNAi_primary
WBRNAi00095108Inferred_automaticallyRNAi_primary
WBRNAi00060918Inferred_automaticallyRNAi_primary
WBRNAi00032061Inferred_automaticallyRNAi_primary
WBRNAi00014699Inferred_automaticallyRNAi_primary
Expr_patternExpr2333
Expr2334
Expr7904
Expr1019495
Expr1030865
Expr1150790
Expr2011810
Expr2030048
Drives_constructWBCnstr00010769
WBCnstr00010770
WBCnstr00012981
WBCnstr00036946
Construct_productWBCnstr00036946
WBCnstr00038797
Microarray_results (19)
Expression_cluster (175)
Interaction (32)
Map_infoMapIIPosition-0.410955Error0.001301
PositivePositive_cloneF40H3Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (20)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene