| WBGene00001434 | SMap | S_parent | Sequence | T14G12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | fkh-2 | Person_evidence | WBPerson411 |
| | | Sequence_name | T14G12.4 |
| | | Molecular_name | T14G12.4a |
| | | | T14G12.4a.1 |
| | | | CE04965 |
| | | | T14G12.4b |
| | | | CE29342 |
| | | | T14G12.4b.1 |
| | | Other_name | CELE_T14G12.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | fkh-2 |
| | DB_info | Database | AceView | gene | XE360 |
| | | | WormQTL | gene | WBGene00001434 |
| | | | WormFlux | gene | WBGene00001434 |
| | | | NDB | locus_tag | CELE_T14G12.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001434|UniProtKB=Q22510 |
| | | | | family | PTHR11829 |
| | | | NCBI | gene | 180663 |
| | | | RefSeq | protein | NM_076243.9 |
| | | | | | NM_001392750.1 |
| | | | SwissProt | UniProtAcc | Q22510 |
| | | | UniProt_GCRP | UniProtAcc | Q22510 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | fkh |
| | Allele (30) |
| | Strain | WBStrain00031566 |
| | | WBStrain00055341 |
| | Component_of_genotype | WBGenotype00000145 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (45) |
| | Paralog | WBGene00003017 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003976 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004013 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001438 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001440 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001441 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001442 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002601 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006853 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000912 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | fkh-2 encodes one of 15 C. elegans forkhead transcription factors and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); fkh-2 is required, along with ceh-37, for proper development of the AWB chemosensory neurons; specifically, fkh-2 is required for development of AWB-specific ciliary and dendritic structures and for positive regulation of expression of genes such as str-1, odr-1, and kap-1; in addition, although loss of fkh-2 activity via RNA-mediated interference (RNAi) results in only mild locomotion defects in L1 larvae, loss of both fkh-2 and pes-1, which also encodes a forkhead transcription factor, results in embryonic and larval lethality; fkh-2 is expressed broadly in embryos in descendants of the D and AB founder cell lineages; postembryonically, FKH-2 is expressed in AWB, and other, chemosensory neurons; fkh-2 expression in AWB is positively regulated by the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00004461 |
| | | | | | WBPaper00005730 |
| | | | | | WBPaper00029400 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 11 Nov 2009 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly. Located in nucleus. Expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Is an ortholog of human FOXG1 (forkhead box G1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Modifies_disease | DOID:1440 |
| Modifies_disease_in_annotation | WBDOannot00001320 |
| Molecular_info | Corresponding_CDS | T14G12.4a |
| | | T14G12.4b |
| | Corresponding_transcript | T14G12.4a.1 |
| | | T14G12.4b.1 |
| | Other_sequence | Dviv_isotig32092 |
| | | JI177266.1 |
| | | Oden_isotig25520 |
| | Associated_feature | WBsf653862 |
| | | WBsf670009 |
| | | WBsf670358 |
| | | WBsf978547 |
| | | WBsf1004702 |
| | | WBsf1004703 |
| | | WBsf1004704 |
| | | WBsf1022665 |
| | | WBsf1022666 |
| | Gene_product_binds (123) |
| | Transcription_factor | WBTranscriptionFactor000165 |
| Experimental_info | RNAi_result | WBRNAi00018725 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075637 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00113574 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00035579 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075636 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00053342 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075638 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1472 |
| | | Expr4692 |
| | | Expr7317 |
| | | Expr7666 |
| | | Expr1013859 |
| | | Expr1030859 |
| | | Expr1156928 |
| | | Expr1200044 |
| | | Expr2011804 |
| | | Expr2030042 |
| | Drives_construct | WBCnstr00000637 |
| | | WBCnstr00012527 |
| | | WBCnstr00012811 |
| | | WBCnstr00036952 |
| | Construct_product | WBCnstr00016700 |
| | | WBCnstr00036952 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00024505:pharyngeal_enriched |
| | | WBPaper00028867:PAL-1_induced_TF |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035197:fer-1_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00040285:H2S_24hr_upregulated |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_2.0uM_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053771:down_by_skn-1(RNAi)_at_3h-NaCl |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056446:hsb-1(cg116)_upregulated |
| | | WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay1 |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_AWC_SAAVx |
| | | WBPaper00061340:Parent_of_exc_gland_AVK |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:SMB |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00064509:static-magnetic-field_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064999:miR-229-64-65-66_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:23_0 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066093:E.coli-purE_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_5 |
| | | WBPaper00025032:cluster_52 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036464:S.aureus-RN6390_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_13 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(143_min) |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (58) |
| Map_info | Map | X | Position | -9.50037 | Error | 0.044105 |
| | Positive | Positive_clone | T14G12 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4310 |
| | | | 4291 |
| | Pseudo_map_position |
| Reference (19) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
