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WormBase Tree Display for Variation: WBVar00088538

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Name Class

WBVar00088538EvidencePaper_evidenceWBPaper00002935
NamePublic_namem26
Other_nameR13H8.1b.1:c.362+1G>A
R13H8.1h.1:c.455+1G>A
R13H8.1l.1:c.53+1G>A
R13H8.1k.1:c.293+1G>A
R13H8.1d.1:c.293+1G>A
R13H8.1m.1:c.53+1G>A
R13H8.1i.1:c.383+1G>A
R13H8.1c.1:c.362+1G>A
R13H8.1f.1:c.383+1G>A
HGVSgCHROMOSOME_I:g.10763707G>A
Sequence_detailsSMapS_parentSequenceR13H8
Flanking_sequencesgcaattctcatcagacatcgtttccttcggatgagctttttcataattattttttggagat
Mapping_targetR13H8
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002935
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00006156
WBStrain00006219
WBStrain00006226
WBStrain00006227
WBStrain00006362
WBStrain00006373
WBStrain00006401
WBStrain00006402
WBStrain00026674
LaboratoryDR
StatusLive
AffectsGeneWBGene00000912
WBGene00305568
TranscriptR13H8.6
R13H8.1i.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1i.1:c.383+1G>A
Intron_number4/10
R13H8.1d.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1d.1:c.293+1G>A
Intron_number3/11
R13H8.1l.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1l.1:c.53+1G>A
Intron_number1/7
R13H8.1k.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1k.1:c.293+1G>A
Intron_number3/9
R13H8.1b.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1b.1:c.362+1G>A
Intron_number2/10
R13H8.1h.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1h.1:c.455+1G>A
Intron_number5/11
R13H8.1f.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1f.1:c.383+1G>A
Intron_number4/12
R13H8.1m.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1m.1:c.53+1G>A
Intron_number1/7
R13H8.1c.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScR13H8.1c.1:c.362+1G>A
Intron_number2/10
Interactor (27)
GeneticsInterpolated_map_positionI5.08422
Mapping_dataIn_2_point441
In_multi_point335
DescriptionPhenotypeWBPhenotype:0000013Paper_evidenceWBPaper00000316
WBPaper00000504
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkDefective dauer formation.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000033Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
RemarkFigure 3. Worms do not respond to population density-dependent acceleration of development (Pdda)Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
WBPhenotype:0000383Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
RemarkWorms had lower levels of synthesized fatty acids compared to N2.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Phenotype_assayTreatmentSynchronized L1s were plated on mixed isotope feeding plates composed of 12C- and 13C-enriched E. coli cultures, and collected after 44-48 hr of feeding (worms were harvested as mid-L4 larvae). All experiments were carried out at 20 deg C.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Temperature20Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
WBPhenotype:0000731Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkWeak increase in levels of apoptosis in daf-16 loss-of-function mutants treated with IRPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006796PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentTreated with 60 Gy IRPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001171Paper_evidenceWBPaper00002149
WBPaper00038458
Curator_confirmedWBPerson712
WBPerson557
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
Phenotype_assayTemperature25.5CPaper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
WBPhenotype:0001655Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
RemarkTable 3Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
WBPhenotype:0002256Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
RemarkIncreased sensitivity to selenium induced movement declinePaper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00001915Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0000061Paper_evidenceWBPaper00005086
WBPaper00040160
WBPaper00001837
Curator_confirmedWBPerson712
RemarkLifespan was not extended by astragalan treatment.Paper_evidenceWBPaper00040160
Curator_confirmedWBPerson712
Lifespans of animals were normal.Paper_evidenceWBPaper00001837
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005124Paper_evidenceWBPaper00040160
Curator_confirmedWBPerson712
Phenotype_assayTemperature15CPaper_evidenceWBPaper00005086
Curator_confirmedWBPerson712
WBPhenotype:0000592Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Remarkdaf-16(m26) mutants did not exhibit a significant change in response to copper, compared to wild typePaper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
WBPhenotype:0000681Paper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
RemarkAnimals are as sensitive as WT.Paper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
WBPhenotype:0000966Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
RemarkAt 20 deg C, the germline was immortal, however a single daf-16 strain became sterile when tested at 25 deg C. The authors note that this single strain may have become homozygous for a sterile, lethal or mortal germline mutation that either arose spontaneously during propagation or was segregating in the un-outcrossed m26 mutant background used for this study. Both daf-16(mu86) and daf-16(mgDf50) did not display this phenotype.Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Phenotype_assayTreatmentStrains propagated for many generations and checked for sterilityPaper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
WBPhenotype:0001616Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkTrimethadione significantly extended life-span of mutant animals (N=58)(1 ind.exp.), although to a less extent than observed for WT animals.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatmentLifespan analysis was performed on animals exposed to 2 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Temperature20CPaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0001617Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkEthosuximide significantly extended life-span of mutant animals (N=119)(3 ind.exp.), as it does for WT animals.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatmentLifespan analysis was performed on animals exposed to 2 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Temperature20CPaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0001653Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Remarkdaf-16(m26) mutants did not exhibit a significant change in response to cadmium, compared to wild typePaper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
WBPhenotype:0002087Paper_evidenceWBPaper00031326
Curator_confirmedWBPerson2857
Remarkgrowth in hydrogen sulfide further enhances thermotolerancePaper_evidenceWBPaper00031326
Curator_confirmedWBPerson2857
WBPhenotype:0002535Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC uptake is normal.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
Reference (32)
MethodSubstitution_allele