WormBase Tree Display for Gene: WBGene00000532

expand all nodes | collapse all nodes | view schema

WBGene00000532	SMap	S_parent	Sequence	CHROMOSOME_II
	Identity	Version	1
		Name	CGC_name	clh-5
			Sequence_name	C07H4.2
			Molecular_name	C07H4.2
				C07H4.2.1
				CE27360
			Other_name	CELE_C07H4.2	Accession_evidence	NDB	BX284602
			Public_name	clh-5
		DB_info	Database (11)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:21	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	clh
		Allele (64)
		Strain	WBStrain00001511
		RNASeq_FPKM (74)
		GO_annotation (16)
		Ortholog (45)
		Paralog	WBGene00000533	Caenorhabditis elegans	From_analysis	TreeFam
						WormBase-Compara
			WBGene00000528	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00000529	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00000530	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00000531	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis.	Paper_evidence	WBPaper00004103
						WBPaper00004883
						WBPaper00012835
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in Golgi apparatus; early endosome; and synaptic vesicle. Expressed in several structures, including head and tail. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome and X-linked recessive disease (multiple). Is an ortholog of human CLCN4 (chloride voltage-gated channel 4).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0111815	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2023)
			DOID:0050699	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2023)
			DOID:0112060	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2022)
			DOID:0111798	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2023)
			DOID:0080353	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2023)
	Molecular_info	Corresponding_CDS	C07H4.2
		Corresponding_CDS_history	C07H4.2:wp48
		Corresponding_transcript	C07H4.2.1
		Other_sequence (49)
		Associated_feature	WBsf223603
	Experimental_info	RNAi_result	WBRNAi00062113	Inferred_automatically	RNAi_primary
			WBRNAi00086835	Inferred_automatically	RNAi_primary
			WBRNAi00065615	Inferred_automatically	RNAi_primary
			WBRNAi00040037	Inferred_automatically	RNAi_primary
			WBRNAi00028650	Inferred_automatically	RNAi_primary
			WBRNAi00077549	Inferred_automatically	RNAi_primary
			WBRNAi00010411	Inferred_automatically	RNAi_primary
		Expr_pattern	Chronogram1083
			Expr1126
			Expr5200
			Expr1027246
			Expr1030318
			Expr1144107
			Expr2010232
			Expr2028474
		Drives_construct	WBCnstr00002368
			WBCnstr00010094
			WBCnstr00037468
		Construct_product	WBCnstr00037468
		Microarray_results (21)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00032528:L3_enriched
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00044656:tatn-1(qd182)_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045521:Gender_Neutral
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00046887:WNT-target
			WBPaper00048762:FOG-3_associated
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_expressed
			WBPaper00049498:npr-1(ur89)_regulated_6
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:intestine_enriched
			WBPaper00050990:intestine_expressed
			WBPaper00051039:germline_enriched
			WBPaper00051265:F4_hrde-1(tm1200)_upregulated
			WBPaper00051265:F4_morc-1(tm6048)_upregulated
			WBPaper00051461:pig-1(gm344)_upregulated
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053289:DREAM-target
			WBPaper00053599:female_vs_male_upregulated
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00053810:isp-1(qm150)_downregulated
			WBPaper00053810:nuo-6(qm200)_downregulated
			WBPaper00054792:FOG-3_interacting
			WBPaper00055334:DLC-1_interacting
			WBPaper00055565:AVK_enriched
			WBPaper00055648:germline_expressed
			WBPaper00055827:pfd-6(gk493446)_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056034:pals-22(jy3)_downregulated
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056443:sek-1(km4)_downregulated
			WBPaper00058691:sin-3(tm1276)_upregulated
			WBPaper00059763:neuron_expressed
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060811:L1_vs_adult_upregulated_neural
			WBPaper00061527:clr-1_21440-mtm-3_16030
			WBPaper00061527:sec-24.1_3187-F07F6.4
			WBPaper00062590:Aging_downregulated_neuron
			WBPaper00064071:NHR-49_interacting
			WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
			WBPaper00064716:paraquat_upregulated
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
			WBPaper00025032:cluster_34
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00030839:Embryo_Pan_Neuronal
			WBPaper00031252:AIN-1_IP_enriched
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00033101:spr-5_regulated
			WBPaper00035905:FBF-1_Associated
			WBPaper00037611:RNP-8-associated
			WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040963:TA300_down
			WBPaper00041002:HF_3d_2.0mM_Down
			WBPaper00041002:HF_11d_2.0mM_Up
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00042331:a-SWCNTs_downregulated
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00045960:L1-L4-lethargus_downregulated
			WBPaper00045960:L4-lethargus_downregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00048989:N2_allantoin_upregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00053236:Starvation_regulated_N2
			[cgc5767]:cluster_54
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_E_pi(23_min)
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MDE
			[cgc5767]:expression_class_MD_pd(41_min)
			[cgc5767]:expression_class_ME
			[cgc6390]:mixed_oogenesis-somatic
		Interaction (31)
	Map_info	Map	II	Position	1.01436	Error	0.007131
		Positive	Positive_clone	C07H4	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4337
				5255
				5491
		Pseudo_map_position
	Reference (17)
	Remark	sequence connection from [George AL]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene