WormBase Tree Display for Gene: WBGene00000530
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| WBGene00000530 | SMap | S_parent | Sequence | E04F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | clh-3 | |||||||
| Sequence_name | E04F6.11 | ||||||||
| Molecular_name (28) | |||||||||
| Other_name | ceclc-3 | Accession_evidence | EMBL | AF173172 | |||||
| CELE_E04F6.11 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | clh-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clh | ||||||||
| Allele (98) | |||||||||
| Strain | WBStrain00002629 | ||||||||
| WBStrain00031612 | |||||||||
| WBStrain00031617 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00000528 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000529 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000531 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000532 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000533 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | clh-3 encodes a chloride channel homologous to the mammalian channel ClC-2; CLH-3 is expressed in oocytes; CLH-3 carries a hyperpolarization- and swelling-activated Cl(-) current, with biophysical characteristics strongly resembling those of mammalian ClC-2; the CLH-3 current is inactive in immature oocytes, but can be triggered by cell swelling, however, CLH-3 has no obvious role in oocyte volume homeostasis; instead, CLH-3 appears to function as a negative regulator of the gap junction-coupled gonadal sheath cells; the normal physiological time for CLH-3 channel activation is at the onset of oocyte meiotic maturation; inactivation of CLH-3 expression by RNAi causes the gonadal sheath cells, which normally begin contracting during meiotic maturation, to instead begin contractions abnormally early. | Paper_evidence | WBPaper00004650 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables voltage-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in egg-laying apparatus; epithelial cell; excretory cell; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Thomsen disease; idiopathic generalized epilepsy 11; and renal tubular transport disease (multiple). Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||
| DOID:0050450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
| DOID:2106 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
| DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026) | ||||||
| DOID:0111312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
| DOID:0110144 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
| DOID:0081336 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
| DOID:0110146 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026,HGNC:2027) | ||||||
| Molecular_info | Corresponding_CDS | E04F6.11a | |||||||
| E04F6.11c | |||||||||
| E04F6.11d | |||||||||
| E04F6.11e | |||||||||
| E04F6.11f | |||||||||
| E04F6.11g | |||||||||
| E04F6.11h | |||||||||
| E04F6.11i | |||||||||
| Corresponding_CDS_history | E04F6.11b:wp86 | ||||||||
| E04F6.11b:wp205 | |||||||||
| E04F6.11b:wp248 | |||||||||
| Corresponding_transcript (12) | |||||||||
| Other_sequence | Oden_isotig25962 | ||||||||
| JI179920.1 | |||||||||
| MHC02649_1 | |||||||||
| MH06173 | |||||||||
| Acan_isotig13455 | |||||||||
| FK805027.1 | |||||||||
| JI180187.1 | |||||||||
| Oden_isotig18922 | |||||||||
| Associated_feature | WBsf665249 | ||||||||
| WBsf665678 | |||||||||
| WBsf223314 | |||||||||
| WBsf223315 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00012687 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001831 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012688 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043676 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007198 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086834 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram425 | ||||||||
| Expr1124 | |||||||||
| Expr1189 | |||||||||
| Expr2718 | |||||||||
| Expr1021775 | |||||||||
| Expr1030317 | |||||||||
| Expr1147660 | |||||||||
| Expr2010230 | |||||||||
| Expr2028472 | |||||||||
| Drives_construct | WBCnstr00003179 | ||||||||
| WBCnstr00010092 | |||||||||
| WBCnstr00010140 | |||||||||
| WBCnstr00018726 | |||||||||
| WBCnstr00018727 | |||||||||
| WBCnstr00018728 | |||||||||
| Construct_product | WBCnstr00018726 | ||||||||
| WBCnstr00018727 | |||||||||
| WBCnstr00018728 | |||||||||
| Antibody | WBAntibody00000721 | ||||||||
| WBAntibody00000884 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | II | Position | 0.499628 | Error | 4.8e-05 | |||
| Positive | Positive_clone | E04F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4568 | |||||||
| 4615 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (33) | |||||||||
| Remark | sequence connection from [George AL] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
