WormBase Tree Display for Gene: WBGene00000530
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WBGene00000530 | SMap | S_parent | Sequence | E04F6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | clh | ||||||
Allele (98) | |||||||
Strain | WBStrain00002629 | ||||||
WBStrain00031612 | |||||||
WBStrain00031617 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (58) | |||||||
Paralog | WBGene00000528 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000529 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000531 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000532 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000533 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | clh-3 encodes a chloride channel homologous to the mammalian channel ClC-2; CLH-3 is expressed in oocytes; CLH-3 carries a hyperpolarization- and swelling-activated Cl(-) current, with biophysical characteristics strongly resembling those of mammalian ClC-2; the CLH-3 current is inactive in immature oocytes, but can be triggered by cell swelling, however, CLH-3 has no obvious role in oocyte volume homeostasis; instead, CLH-3 appears to function as a negative regulator of the gap junction-coupled gonadal sheath cells; the normal physiological time for CLH-3 channel activation is at the onset of oocyte meiotic maturation; inactivation of CLH-3 expression by RNAi causes the gonadal sheath cells, which normally begin contracting during meiotic maturation, to instead begin contractions abnormally early. | Paper_evidence | WBPaper00004650 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables voltage-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in egg-laying apparatus; epithelial cell; excretory cell; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Thomsen disease; idiopathic generalized epilepsy 11; and renal tubular transport disease (multiple). Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||
DOID:0050450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||
DOID:2106 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||
DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026) | ||||
DOID:0111312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||
DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||
DOID:0110144 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||
DOID:0081336 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||
DOID:0110146 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026,HGNC:2027) | ||||
Molecular_info | Corresponding_CDS | E04F6.11a | |||||
E04F6.11c | |||||||
E04F6.11d | |||||||
E04F6.11e | |||||||
E04F6.11f | |||||||
E04F6.11g | |||||||
E04F6.11h | |||||||
E04F6.11i | |||||||
Corresponding_CDS_history | E04F6.11b:wp86 | ||||||
E04F6.11b:wp205 | |||||||
E04F6.11b:wp248 | |||||||
Corresponding_transcript (12) | |||||||
Other_sequence | Oden_isotig25962 | ||||||
JI179920.1 | |||||||
MHC02649_1 | |||||||
MH06173 | |||||||
Acan_isotig13455 | |||||||
FK805027.1 | |||||||
JI180187.1 | |||||||
Oden_isotig18922 | |||||||
Associated_feature | WBsf665249 | ||||||
WBsf665678 | |||||||
WBsf223314 | |||||||
WBsf223315 | |||||||
Experimental_info | RNAi_result | WBRNAi00012687 | Inferred_automatically | RNAi_primary | |||
WBRNAi00001831 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00012688 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00043676 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00007198 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077551 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086834 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram425 | ||||||
Expr1124 | |||||||
Expr1189 | |||||||
Expr2718 | |||||||
Expr1021775 | |||||||
Expr1030317 | |||||||
Expr1147660 | |||||||
Expr2010230 | |||||||
Expr2028472 | |||||||
Drives_construct | WBCnstr00003179 | ||||||
WBCnstr00010092 | |||||||
WBCnstr00010140 | |||||||
WBCnstr00018726 | |||||||
WBCnstr00018727 | |||||||
WBCnstr00018728 | |||||||
Construct_product | WBCnstr00018726 | ||||||
WBCnstr00018727 | |||||||
WBCnstr00018728 | |||||||
Antibody | WBAntibody00000721 | ||||||
WBAntibody00000884 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (114) | |||||||
Interaction (12) | |||||||
Map_info | Map | II | Position | 0.499628 | Error | 4.8e-05 | |
Positive | Positive_clone | E04F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4568 | |||||
4615 | |||||||
Pseudo_map_position | |||||||
Reference (33) | |||||||
Remark | sequence connection from [George AL] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |