WormBase Tree Display for Gene: WBGene00000528
expand all nodes | collapse all nodes | view schema
| WBGene00000528 | SMap | S_parent | Sequence | T27D12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | clh-1 | |||||||
| Sequence_name | T27D12.2 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | CELE_T27D12.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | clh-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clh | ||||||||
| Allele (219) | |||||||||
| Strain | WBStrain00031546 | ||||||||
| WBStrain00040608 | |||||||||
| WBStrain00040609 | |||||||||
| WBStrain00051725 | |||||||||
| WBStrain00051724 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00000530 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000531 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000529 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000532 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000533 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | clh-1 encodes two CLC-type chloride channels via alternative splicing, homologous to human CLC1 (OMIM:118425) and CLC2 (OMIM:600570); CLH-1a and CLH-1b are required for maintenance of normal body shape; null mutations of clh-1 cause abnormal alae and a wider body than normal, with the body phenotype being reversible by culture medium of high osmolarity. | Paper_evidence | WBPaper00003816 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Expressed in several structures, including amphid sensillum; anterior hypodermis; cephalic sheath cell; spermatheca; and vulval cell. Human ortholog(s) of this gene implicated in Thomsen disease; idiopathic generalized epilepsy 11; and primary hyperaldosteronism. Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||
| DOID:0081336 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
| DOID:2106 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
| DOID:0111312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||||
| Molecular_info | Corresponding_CDS | T27D12.2a | |||||||
| T27D12.2b | |||||||||
| T27D12.2c | |||||||||
| T27D12.2d | |||||||||
| T27D12.2e | |||||||||
| T27D12.2f | |||||||||
| T27D12.2g | |||||||||
| Corresponding_CDS_history | T27D12.2:wp49 | ||||||||
| Corresponding_transcript | T27D12.2a.1 | ||||||||
| T27D12.2b.1 | |||||||||
| T27D12.2c.1 | |||||||||
| T27D12.2d.1 | |||||||||
| T27D12.2e.1 | |||||||||
| T27D12.2f.1 | |||||||||
| T27D12.2g.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00019329 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00054307 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077546 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr978 | ||||||||
| Expr1121 | |||||||||
| Expr12665 | |||||||||
| Expr15673 | |||||||||
| Expr1013381 | |||||||||
| Expr1030315 | |||||||||
| Expr1157851 | |||||||||
| Expr2010228 | |||||||||
| Expr2028470 | |||||||||
| Drives_construct | WBCnstr00010089 | ||||||||
| WBCnstr00013831 | |||||||||
| WBCnstr00037471 | |||||||||
| WBCnstr00042471 | |||||||||
| Construct_product | WBCnstr00037471 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | II | Position | 4.08004 | Error | 0.003234 | |||
| Positive | Positive_clone | T27D12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4224 | |||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | sequence connection from [George AL] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
