WormBase Tree Display for Gene: WBGene00000530
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WBGene00000530 | SMap | S_parent | Sequence | E04F6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | clh-3 | |||||||
Sequence_name | E04F6.11 | ||||||||
Molecular_name (28) | |||||||||
Other_name | ceclc-3 | Accession_evidence | EMBL | AF173172 | |||||
CELE_E04F6.11 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | clh-3 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | clh | ||||||||
Allele (98) | |||||||||
Strain (3) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Ortholog (58) | |||||||||
Paralog | WBGene00000528 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000529 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000531 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000532 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000533 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | clh-3 encodes a chloride channel homologous to the mammalian channel ClC-2; CLH-3 is expressed in oocytes; CLH-3 carries a hyperpolarization- and swelling-activated Cl(-) current, with biophysical characteristics strongly resembling those of mammalian ClC-2; the CLH-3 current is inactive in immature oocytes, but can be triggered by cell swelling, however, CLH-3 has no obvious role in oocyte volume homeostasis; instead, CLH-3 appears to function as a negative regulator of the gap junction-coupled gonadal sheath cells; the normal physiological time for CLH-3 channel activation is at the onset of oocyte meiotic maturation; inactivation of CLH-3 expression by RNAi causes the gonadal sheath cells, which normally begin contracting during meiotic maturation, to instead begin contractions abnormally early. | Paper_evidence | WBPaper00004650 | |||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables voltage-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in egg-laying apparatus; epithelial cell; excretory cell; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Thomsen disease; idiopathic generalized epilepsy 11; and renal tubular transport disease (multiple). Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||
DOID:0050450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
DOID:2106 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026) | ||||||
DOID:0111312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2020) | ||||||
DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
DOID:0110144 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2027) | ||||||
DOID:0081336 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2019) | ||||||
DOID:0110146 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2026,HGNC:2027) | ||||||
Molecular_info | Corresponding_CDS | E04F6.11a | |||||||
E04F6.11c | |||||||||
E04F6.11d | |||||||||
E04F6.11e | |||||||||
E04F6.11f | |||||||||
E04F6.11g | |||||||||
E04F6.11h | |||||||||
E04F6.11i | |||||||||
Corresponding_CDS_history | E04F6.11b:wp86 | ||||||||
E04F6.11b:wp205 | |||||||||
E04F6.11b:wp248 | |||||||||
Corresponding_transcript (12) | |||||||||
Other_sequence | Oden_isotig25962 | ||||||||
JI179920.1 | |||||||||
MHC02649_1 | |||||||||
MH06173 | |||||||||
Acan_isotig13455 | |||||||||
FK805027.1 | |||||||||
JI180187.1 | |||||||||
Oden_isotig18922 | |||||||||
Associated_feature | WBsf665249 | ||||||||
WBsf665678 | |||||||||
WBsf223314 | |||||||||
WBsf223315 | |||||||||
Experimental_info | RNAi_result | WBRNAi00012687 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001831 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00012688 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00043676 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00007198 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077551 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00086834 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram425 | ||||||||
Expr1124 | |||||||||
Expr1189 | |||||||||
Expr2718 | |||||||||
Expr1021775 | |||||||||
Expr1030317 | |||||||||
Expr1147660 | |||||||||
Expr2010230 | |||||||||
Expr2028472 | |||||||||
Drives_construct | WBCnstr00003179 | ||||||||
WBCnstr00010092 | |||||||||
WBCnstr00010140 | |||||||||
WBCnstr00018726 | |||||||||
WBCnstr00018727 | |||||||||
WBCnstr00018728 | |||||||||
Construct_product | WBCnstr00018726 | ||||||||
WBCnstr00018727 | |||||||||
WBCnstr00018728 | |||||||||
Antibody | WBAntibody00000721 | ||||||||
WBAntibody00000884 | |||||||||
Microarray_results (30) | |||||||||
Expression_cluster (114) | |||||||||
Interaction (12) | |||||||||
Map_info | Map | II | Position | 0.499628 | Error | 4.8e-05 | |||
Positive | Positive_clone | E04F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4568 | |||||||
4615 | |||||||||
Pseudo_map_position | |||||||||
Reference (33) | |||||||||
Remark | sequence connection from [George AL] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |