WormBase Tree Display for Gene: WBGene00000529

WBGene00000529 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: clh-2
      Sequence_name: B0491.8
      Molecular_name: B0491.8a
        B0491.8a.1
        CE53983
        B0491.8b
        CE27790
        B0491.8c
        CE02153
        B0491.8b.1
        B0491.8c.1
      Other_name: ceclc-2 Accession_evidence: EMBL AF173171
        clc-2
        CELE_B0491.8 Accession_evidence: NDB BX284602
      Public_name: clh-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clh
    Allele (279)
    Strain: WBStrain00031534
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (45)
    Paralog: WBGene00000528 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000530 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000531 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000532 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000533 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: clh-2 encodes a chloride channel protein that is required for embryonic viability; may have two transcripts transcribed from alternative promoters, and the two transcripts might be expressed in different cell types. Paper_evidence: WBPaper00003797
            WBPaper00004423
            WBPaper00004651
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Expressed in several structures, including ganglia; intestine; pharyngeal-intestinal valve; somatic nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in Thomsen disease; idiopathic generalized epilepsy 11; and primary hyperaldosteronism. Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:446 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
      DOID:0081336 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:2106 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:0111312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
  Molecular_info: Corresponding_CDS: B0491.8a
      B0491.8b
      B0491.8c
    Corresponding_CDS_history: B0491.8a:wp274
    Corresponding_transcript: B0491.8a.1
      B0491.8b.1
      B0491.8c.1
    Other_sequence (26)
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00011514 Inferred_automatically: RNAi_primary
      WBRNAi00000398 Inferred_automatically: RNAi_primary
      WBRNAi00077547 Inferred_automatically: RNAi_primary
      WBRNAi00039107 Inferred_automatically: RNAi_primary
      WBRNAi00009806 Inferred_automatically: RNAi_primary
      WBRNAi00039106 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1122
      Expr1123
      Expr1188
      Expr1024352
      Expr1030316
      Expr1143264
      Expr2010229
      Expr2028471
    Drives_construct: WBCnstr00010090
      WBCnstr00010091
      WBCnstr00010139
      WBCnstr00037470
    Construct_product: WBCnstr00037470
    Microarray_results (36)
    Expression_cluster: WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047132:skn-1(RNAi)_downregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:mdt-15(mg584)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061357:mett-10(ok2204)_upregulated_OP50
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:rgs-2_11061-pde-1
      WBPaper00061527:xbx-3-DH11.5_20397
      WBPaper00061651:AVA_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064532:pals-25(jy111)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:29_0
      WBPaper00065841:46_0
      WBPaper00065841:49_0
      WBPaper00065841:56_0
      WBPaper00065841:61_0
      WBPaper00065841:67_0
      WBPaper00065841:73_0
      WBPaper00065841:83_0
      WBPaper00065841:87_0
      WBPaper00065841:90_0
      WBPaper00065841:98_0
      WBPaper00065841:111_0
      WBPaper00065841:122_0
      WBPaper00065841:134_0
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_18
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00045294:0.1uM_DBAA_downregulated
      WBPaper00046853:AOBr_LakeStobenseeAug_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048563:L1_DD_enriched
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
    Interaction: WBInteraction000133971
      WBInteraction000133972
      WBInteraction000135502
      WBInteraction000135503
      WBInteraction000138010
  Map_info: Map: II Position: 3.45766 Error: 0.002945
    Positive: Positive_clone: B0491 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: sequence connection from [George AL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene