WormBase Tree Display for Gene: WBGene00000302

WBGene00000302 SMap: S_parent: Sequence: C56A3
  Identity: Version: 1
    Name: CGC_name: cav-2 Person_evidence: WBPerson464
      Sequence_name: C56A3.7
      Molecular_name (12)
      Other_name: CELE_C56A3.7 Accession_evidence: NDB BX284605
      Public_name: cav-2
    DB_info: Database: AceView gene 5O39
        WormQTL gene WBGene00000302
        WormFlux gene WBGene00000302
        NDB locus_tag CELE_C56A3.7
        Panther gene CAEEL|WormBase=WBGene00000302|UniProtKB=Q18879
          family PTHR10844
        NCBI gene 179838
        RefSeq protein NM_001269596.3
            NM_001269595.3
            NM_001269594.3
            NM_001269597.3
        SwissProt UniProtAcc Q18879
        TREEFAM TREEFAM_ID TF315736
        UniProt_GCRP UniProtAcc Q18879
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cav
    Allele (89)
    Legacy_information: No mutants known. Encodes predicted 261aa protein, 28% identical to cav-1. Residues 214-351 have 24% identity to mammalian caveolins. 2.4 kb transcript detected. Predicted gene C56A3.7
    Strain: WBStrain00000430
      WBStrain00003572
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (25)
    Paralog: WBGene00000301 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: cav-2 encodes one of two C. elegans proteins related to caveolins, integral transmembrane proteins that are believed to function in regulation of signal transduction and that are the major component of caveolae, specialized lipid rafts found in the plasma membrane of most cell types; as loss of cav-2 function via large-scale RNA-mediated interference (RNAi) screens does not result in any obvious abnormalities, the role of cav-2 in C. elegans development and/or behavior is not yet known; cav-2 mRNA is expressed in eggs and mixed stage populations. Paper_evidence: WBPaper00002653
            WBPaper00003590
            WBPaper00005654
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables lipid transporter activity. Involved in parturition and regulation of egg-laying behavior. Located in apical plasma membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C56A3.7a
      C56A3.7b
      C56A3.7c
      C56A3.7d
    Corresponding_transcript: C56A3.7a.1
      C56A3.7b.1
      C56A3.7c.1
      C56A3.7d.1
    Other_sequence (12)
    Associated_feature: WBsf647464
      WBsf1001843
      WBsf1001844
      WBsf232786
      WBsf232787
  Experimental_info: RNAi_result: WBRNAi00043257 Inferred_automatically: RNAi_primary
      WBRNAi00102916 Inferred_automatically: RNAi_primary
      WBRNAi00102917 Inferred_automatically: RNAi_primary
      WBRNAi00102909 Inferred_automatically: RNAi_primary
      WBRNAi00027704 Inferred_automatically: RNAi_primary
      WBRNAi00012452 Inferred_automatically: RNAi_primary
      WBRNAi00102915 Inferred_automatically: RNAi_primary
      WBRNAi00102910 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram499
      Expr2724
      Expr5596
      Expr12158
      Expr1020786
      Expr1030193
      Expr1147237
      Expr2009737
      Expr2027977
    Drives_construct: WBCnstr00004024
      WBCnstr00020296
      WBCnstr00020297
      WBCnstr00020479
      WBCnstr00037594
    Construct_product: WBCnstr00020296
      WBCnstr00020479
      WBCnstr00020480
      WBCnstr00037594
    Antibody: WBAntibody00002615
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:Cluster_1
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_zfp-1
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_downregulated
      WBPaper00037946:EGL-5_interacting
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00049177:rpn-10(ok1865)_upregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ALN
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_downregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:18_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_5_5
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031184:acrylamide_downregulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction (14)
  Map_info: Map: V Position: 5.45137 Error: 0.007118
    Positive: Positive_clone: C56A3 Person_evidence: WBPerson464
          Author_evidence: Tang Z
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4176
        4324
    Pseudo_map_position
  Reference: WBPaper00002653
    WBPaper00003590
    WBPaper00004384
    WBPaper00006323
    WBPaper00024791
    WBPaper00027612
    WBPaper00028448
    WBPaper00035456
    WBPaper00046406
    WBPaper00055090
  Remark: Data extracted from Tang et al. (1997)
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene