WormBase Tree Display for Expr_pattern: Expr12158
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| Expr12158 | Expression_of | Gene | WBGene00000302 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00000302 | |||
| Expression_data | Anatomy_term | WBbt:0005772 | Certain | |
| GO_term | GO:0016324 | |||
| Subcellular_localization | Both cav-2::gfp fusion proteins localized to the apical side of the intestinal cells, very close to or within the membrane. Expression was first detected in midstage embryos and continued thence forward. The expression at the apical membrane was highest and most evenly distributed in L1 and L2 animals. With maturation, levels of CAV-2 were highest at the anterior and posterior cells of the intestine. Interestingly, the labeling of the membrane was discontinuous. We also observed the presence of discrete, spherically shaped, CAV-2::GFP-positive vesicles (diameter, 1.6 um; n=30). These vesicles were most common at the posterior end of the gut and were distinct from autofluorescent gut granules (AFGGs), which are terminal endocytic lysosomes. We call these structures CAV-2 bodies, as their relationship to mammalian caveosomes is unknown. | |||
| Type | Antibody | |||
| Reporter_gene | ||||
| Pattern | cav-2::GFP fusions were expressed in the intestine of hermaphrodite and male wild-type animals. Expression was not detected in any other tissues. This pattern was confirmed with an anti-CAV-2 antibody. | |||
| Picture | WBPicture0000013901 | |||
| Reference | WBPaper00046406 | |||
| Transgene | WBTransgene00031751 | |||
| WBTransgene00031752 | ||||
| Antibody_info | WBAntibody00002615 |
