WormBase Tree Display for Gene: WBGene00000173

WBGene00000173 Evidence: Person_evidence: WBPerson548
  SMap: S_parent: Sequence: C35A5
  Identity: Version: 1
    Name: CGC_name: aqp-5 Person_evidence: WBPerson300
      Sequence_name: C35A5.1
      Molecular_name: C35A5.1
        C35A5.1.1
        CE42929
      Other_name: CELE_C35A5.1 Accession_evidence: NDB BX284605
      Public_name: aqp-5
    DB_info: Database: AceView gene 5K969
        WormQTL gene WBGene00000173
        WormFlux gene WBGene00000173
        NDB locus_tag CELE_C35A5.1
        Panther gene CAEEL|WormBase=WBGene00000173|UniProtKB=Q18469
          family PTHR45665
        NCBI gene 183221
        RefSeq protein NM_073290.5
        TrEMBL UniProtAcc Q18469
        UniProt_GCRP UniProtAcc Q18469
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aqp
    Allele (24)
    RNASeq_FPKM (74)
    GO_annotation: 00061317
      00061318
      00061319
      00061320
      00061321
      00061322
      00106939
      00106940
      00106941
    Ortholog (29)
    Paralog: WBGene00000172 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000174 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000169 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000170 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000171 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000175 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000176 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: aqp-5 encodes a putative aquaporin with no known substrate, since AQP-5 expressed in Xenopus oocytes has no effect on water, glycerol, or urea permeability; AQP-5 also has no function in mass RNAi assays, perhaps reflecting genetic redundancy with its paralogs AQP-4 and AQP-6; AQP-5 is expressed in I1 and I2 pharyngeal interneurons, and is orthologous to human AQP8 (OMIM:603750). Paper_evidence: WBPaper00029039
            WBPaper00030907
          Curator_confirmed: WBPerson567
          Date_last_updated: 12 Aug 2007 00:00:00
      Automated_description: Predicted to enable water channel activity. Predicted to be involved in water transport. Located in cell surface. Expressed in I1L; I1R; I2L; and I2R. Is an ortholog of human AQP8 (aquaporin 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C35A5.1
    Corresponding_CDS_history: C35A5.1:wp193
    Corresponding_transcript: C35A5.1.1
    Other_sequence: FG647856.1
    Associated_feature: WBsf647162
      WBsf232386
  Experimental_info: RNAi_result: WBRNAi00041945 Inferred_automatically: RNAi_primary
      WBRNAi00029560 Inferred_automatically: RNAi_primary
      WBRNAi00011639 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4775
      Expr15317
      Expr1013541
      Expr1030098
      Expr1145952
      Expr2009382
      Expr2027618
    Drives_construct: WBCnstr00012235
      WBCnstr00037687
    Construct_product: WBCnstr00037687
    Microarray_results (18)
    Expression_cluster: WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00049334:CE_intestine_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00058969:RIS_depleted
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated
      WBPaper00061340:MC
      WBPaper00061527:srj-21-srh-32
      WBPaper00061651:I2_enriched
      WBPaper00061651:M3_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:39_0
      WBPaper00065841:39_1
      WBPaper00065841:58_0
      WBPaper00065841:58_1
      WBPaper00065841:107_0
      WBPaper00065841:125_0
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4489_group_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
    Interaction (60)
  Map_info: Map: V Position: 2.57003 Error: 0.000173
    Positive: Positive_clone: C35A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027012
    WBPaper00029039
    WBPaper00033469
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene