Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000172

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00000172EvidencePerson_evidenceWBPerson548
SMapS_parentSequenceCHROMOSOME_V
IdentityVersion1
NameCGC_nameaqp-4Person_evidenceWBPerson300
Sequence_nameF40F9.9
Molecular_nameF40F9.9
F40F9.9.1
CE31345
Other_nameCELE_F40F9.9Accession_evidenceNDBBX284605
Public_nameaqp-4
DB_infoDatabaseAceViewgene5K225
WormQTLgeneWBGene00000172
WormFluxgeneWBGene00000172
NDBlocus_tagCELE_F40F9.9
PanthergeneCAEEL|WormBase=WBGene00000172|UniProtKB=G5EEK0
familyPTHR45665
NCBIgene179366
RefSeqproteinNM_073111.8
TrEMBLUniProtAccG5EEK0
UniProt_GCRPUniProtAccG5EEK0
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaqp
Allele (37)
StrainWBStrain00032651
WBStrain00007586
RNASeq_FPKM (74)
GO_annotation (12)
Ortholog (40)
ParalogWBGene00000174Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
WBGene00000173Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000169Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000170Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000171Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000175Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000176Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionaqp-4 encodes an aquaporin whose expression in Xenopus oocytes increases water permeability 5- to 10-fold; loss of AQP-4 activity via mutation or RNAi results in no obvious defects; however, AQP-4, in conjunction with AQP-2, AQP-3, and AQP-8, is weakly required for recovery from hypotonic stress; AQP-4 is expressed in the apical membrane of intestine; AQP-4 is paralogous to AQP-5 and AQP-6, and orthologous to human AQP8 (OMIM:603750).Paper_evidenceWBPaper00004488
WBPaper00029039
WBPaper00030907
Curator_confirmedWBPerson567
Date_last_updated12 Aug 2007 00:00:00
Automated_descriptionEnables water channel activity. Involved in water transport. Located in apical plasma membrane. Expressed in intestine. Is an ortholog of human AQP8 (aquaporin 8).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF40F9.9
Corresponding_CDS_historyF40F9.9:wp82
Corresponding_transcriptF40F9.9.1
Other_sequence (17)
Associated_featureWBsf647105
WBsf232292
Experimental_infoRNAi_resultWBRNAi00014675Inferred_automaticallyRNAi_primary
WBRNAi00046891Inferred_automaticallyRNAi_primary
WBRNAi00101341Inferred_automaticallyRNAi_primary
WBRNAi00032043Inferred_automaticallyRNAi_primary
WBRNAi00101339Inferred_automaticallyRNAi_primary
Expr_patternExpr4774
Expr1019243
Expr1030097
Expr1150757
Expr2009381
Expr2027617
Drives_constructWBCnstr00012234
WBCnstr00017547
WBCnstr00037688
Construct_productWBCnstr00012234
WBCnstr00017547
WBCnstr00037688
Microarray_results (16)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00036231:long-telomeres_downregulated
WBPaper00037055:DAF-16_binding_DNA
WBPaper00038237:age-1_upregulated_intestine_rescue
WBPaper00038237:age-1_upregulated_neuron_rescue
WBPaper00038237:age-1_upregulated_nontransgenic
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044316:CH3HgCl_7.5uM_downregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046121:endoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048923:Aging_regulated
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050903:mir-35-41(nDf50)_25C_downregulated
WBPaper00050990:intestine_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:cytoplasm_specific
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_specific
WBPaper00051257:Levamisole_downregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055827:daf-2(e1370)_downregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056161:male_enriched_siRNA
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
WBPaper00056586:kri-1(ok1251)_upregulated
WBPaper00056731:human-amylin_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:hmc_biased
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057068:ints-4(RNAi)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060871:M.humicola-extract_4h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:microgravity_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061527:ifd-1-ifp-1
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062669:extracellular-vesicle_protein
WBPaper00062684:pathogen_upregulated_CB4856
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_downregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065029:cadmium_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:94_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066093:E.coli-purE_upregulated
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
cgc4386_cluster_3_5
cgc4489_group_3
WBPaper00006465:IV_ethanol_late_repression
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026952:class_A
WBPaper00029437:rde-4_upregulated
WBPaper00031003:hlh_1_enriched
WBPaper00034757:down_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035892:Y.pestis_regulated
WBPaper00037695:WC_5-day
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00040876:mir-35_downregulated
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040963:TA300_up
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00045960:L4-lethargus_upregulated
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00050767:Octopamine_induced
[cgc6390]:Cluster_C
Interaction (31)
Map_infoMapVPosition2.13466Error0.004141
PositivePositive_cloneF40F9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00004488
WBPaper00010068
WBPaper00019560
WBPaper00027012
WBPaper00029039
WBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene