WormBase Tree Display for Gene: WBGene00000170
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WBGene00000170 | Evidence | Person_evidence | WBPerson548 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C01G6 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | aqp | ||||||
Allele (52) | |||||||
Strain | WBStrain00032407 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (47) | |||||||
Paralog | WBGene00000169 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000176 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000175 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00000171 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress. | Paper_evidence | WBPaper00003343 | |||
WBPaper00013089 | |||||||
WBPaper00025051 | |||||||
WBPaper00027009 | |||||||
WBPaper00027351 | |||||||
WBPaper00029039 | |||||||
WBPaper00030907 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 12 Aug 2007 00:00:00 | ||||||
Automated_description | Enables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) | ||
DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||
DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||
DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||
DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||
Molecular_info | Corresponding_CDS | C01G6.1a | |||||
C01G6.1b | |||||||
Corresponding_transcript | C01G6.1a.1 | ||||||
C01G6.1b.1 | |||||||
C01G6.1b.2 | |||||||
Other_sequence (55) | |||||||
Associated_feature (22) | |||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern | Expr4772 | ||||||
Expr1017046 | |||||||
Expr1030096 | |||||||
Expr1143468 | |||||||
Expr2009380 | |||||||
Expr2027616 | |||||||
Drives_construct | WBCnstr00012232 | ||||||
WBCnstr00037690 | |||||||
Construct_product | WBCnstr00037690 | ||||||
Microarray_results (37) | |||||||
Expression_cluster (293) | |||||||
Interaction (19) | |||||||
Map_info | Map | II | Position | 1.09711 | Error | 0.000462 | |
Positive | Positive_clone | C01G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |