WormBase Tree Display for Gene: WBGene00000170
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WBGene00000170 | Evidence | Person_evidence | WBPerson548 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C01G6 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | aqp-2 | Person_evidence | WBPerson300 | |||||
Sequence_name | C01G6.1 | ||||||||
Molecular_name | C01G6.1a | ||||||||
C01G6.1a.1 | |||||||||
CE00863 | |||||||||
C01G6.1b | |||||||||
CE19664 | |||||||||
C01G6.1b.1 | |||||||||
C01G6.1b.2 | |||||||||
Other_name | CELE_C01G6.1 | Accession_evidence | NDB | BX284602 | |||||
Public_name | aqp-2 | ||||||||
DB_info | Database | AceView | gene | 2J550 | |||||
WormQTL | gene | WBGene00000170 | |||||||
WormFlux | gene | WBGene00000170 | |||||||
NDB | locus_tag | CELE_C01G6.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000170|UniProtKB=Q17571 | |||||||
family | PTHR43829 | ||||||||
NCBI | gene | 174467 | |||||||
RefSeq | protein | NM_001393149.1 | |||||||
NM_001381560.2 | |||||||||
TREEFAM | TREEFAM_ID | TF313173 | |||||||
TrEMBL | UniProtAcc | Q17571 | |||||||
Q7JMQ6 | |||||||||
UniProt_GCRP | UniProtAcc | Q17571 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | aqp | ||||||||
Allele (52) | |||||||||
Strain | WBStrain00032407 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (47) | |||||||||
Paralog | WBGene00000169 | Caenorhabditis elegans | From_analysis (2) | ||||||
WBGene00000176 | Caenorhabditis elegans | From_analysis (2) | |||||||
WBGene00000175 | Caenorhabditis elegans | From_analysis (2) | |||||||
WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00000171 | Caenorhabditis elegans | From_analysis (2) | |||||||
WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress. | Paper_evidence | WBPaper00003343 | |||||
WBPaper00013089 | |||||||||
WBPaper00025051 | |||||||||
WBPaper00027009 | |||||||||
WBPaper00027351 | |||||||||
WBPaper00029039 | |||||||||
WBPaper00030907 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 12 Aug 2007 00:00:00 | ||||||||
Automated_description | Enables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) | ||||
DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
Molecular_info | Corresponding_CDS | C01G6.1a | |||||||
C01G6.1b | |||||||||
Corresponding_transcript | C01G6.1a.1 | ||||||||
C01G6.1b.1 | |||||||||
C01G6.1b.2 | |||||||||
Other_sequence (55) | |||||||||
Associated_feature (22) | |||||||||
Experimental_info | RNAi_result (13) | ||||||||
Expr_pattern | Expr4772 | ||||||||
Expr1017046 | |||||||||
Expr1030096 | |||||||||
Expr1143468 | |||||||||
Expr2009380 | |||||||||
Expr2027616 | |||||||||
Drives_construct | WBCnstr00012232 | ||||||||
WBCnstr00037690 | |||||||||
Construct_product | WBCnstr00037690 | ||||||||
Microarray_results (37) | |||||||||
Expression_cluster (293) | |||||||||
Interaction (19) | |||||||||
Map_info | Map | II | Position | 1.09711 | Error | 0.000462 | |||
Positive | Positive_clone | C01G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (13) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |