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WormBase Tree Display for Gene: WBGene00000170

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Name Class

WBGene00000170EvidencePerson_evidenceWBPerson548
SMapS_parentSequenceC01G6
IdentityVersion1
NameCGC_nameaqp-2Person_evidenceWBPerson300
Sequence_nameC01G6.1
Molecular_nameC01G6.1a
C01G6.1a.1
CE00863
C01G6.1b
CE19664
C01G6.1b.1
C01G6.1b.2
Other_nameCELE_C01G6.1Accession_evidenceNDBBX284602
Public_nameaqp-2
DB_infoDatabaseAceViewgene2J550
WormQTLgeneWBGene00000170
WormFluxgeneWBGene00000170
NDBlocus_tagCELE_C01G6.1
PanthergeneCAEEL|WormBase=WBGene00000170|UniProtKB=Q17571
familyPTHR43829
NCBIgene174467
RefSeqproteinNM_001393149.1
NM_001381560.2
TREEFAMTREEFAM_IDTF313173
TrEMBLUniProtAccQ17571
Q7JMQ6
UniProt_GCRPUniProtAccQ17571
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaqp
Allele (52)
StrainWBStrain00032407
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (47)
ParalogWBGene00000169Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000176Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000175Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013272Caenorhabditis elegansFrom_analysisPanther
WBGene00000171Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000172Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000173Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000174Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionaqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress.Paper_evidenceWBPaper00003343
WBPaper00013089
WBPaper00025051
WBPaper00027009
WBPaper00027351
WBPaper00029039
WBPaper00030907
Curator_confirmedWBPerson1843
Date_last_updated12 Aug 2007 00:00:00
Automated_descriptionEnables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4724Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:636)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:0060180Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:11981Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
Molecular_infoCorresponding_CDSC01G6.1a
C01G6.1b
Corresponding_transcriptC01G6.1a.1
C01G6.1b.1
C01G6.1b.2
Other_sequence (55)
Associated_feature (22)
Experimental_infoRNAi_resultWBRNAi00039350Inferred_automaticallyRNAi_primary
WBRNAi00079475Inferred_automaticallyRNAi_primary
WBRNAi00079521Inferred_automaticallyRNAi_primary
WBRNAi00079659Inferred_automaticallyRNAi_primary
WBRNAi00101341Inferred_automaticallyRNAi_primary
WBRNAi00079613Inferred_automaticallyRNAi_primary
WBRNAi00079705Inferred_automaticallyRNAi_primary
WBRNAi00039351Inferred_automaticallyRNAi_primary
WBRNAi00079751Inferred_automaticallyRNAi_primary
WBRNAi00028302Inferred_automaticallyRNAi_primary
WBRNAi00101337Inferred_automaticallyRNAi_primary
WBRNAi00079797Inferred_automaticallyRNAi_primary
WBRNAi00079567Inferred_automaticallyRNAi_primary
Expr_patternExpr4772
Expr1017046
Expr1030096
Expr1143468
Expr2009380
Expr2027616
Drives_constructWBCnstr00012232
WBCnstr00037690
Construct_productWBCnstr00037690
Microarray_results (37)
Expression_cluster (293)
Interaction (19)
Map_infoMapIIPosition1.09711Error0.000462
PositivePositive_cloneC01G6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (13)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene