WormBase Tree Display for Gene: WBGene00000170

WBGene00000170 Evidence: Person_evidence: WBPerson548
  SMap: S_parent: Sequence: C01G6
  Identity: Version: 1
    Name: CGC_name: aqp-2 Person_evidence: WBPerson300
      Sequence_name: C01G6.1
      Molecular_name: C01G6.1a
        C01G6.1a.1
        CE00863
        C01G6.1b
        CE19664
        C01G6.1b.1
        C01G6.1b.2
      Other_name: CELE_C01G6.1 Accession_evidence: NDB BX284602
      Public_name: aqp-2
    DB_info: Database: AceView gene 2J550
        WormQTL gene WBGene00000170
        WormFlux gene WBGene00000170
        NDB locus_tag CELE_C01G6.1
        Panther gene CAEEL|WormBase=WBGene00000170|UniProtKB=Q17571
          family PTHR43829
        NCBI gene 174467
        RefSeq protein NM_001393149.1
            NM_001381560.2
        TREEFAM TREEFAM_ID TF313173
        TrEMBL UniProtAcc Q17571
            Q7JMQ6
        UniProt_GCRP UniProtAcc Q17571
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aqp
    Allele: WBVar02149947
      WBVar01696109
      WBVar01499702
      WBVar01498435
      WBVar01604429
      WBVar01499017
      WBVar00105277
      WBVar00755177
      WBVar00755178
      WBVar00755179
      WBVar00755180
      WBVar00755181
      WBVar00755182
      WBVar00755183
      WBVar00755184
      WBVar00755185
      WBVar00755186
      WBVar00174543
      WBVar00755187
      WBVar00755188
      WBVar02018106
      WBVar00755189
      WBVar00755190
      WBVar00373746
      WBVar00755191
      WBVar00373747
      WBVar00373748
      WBVar00755192
      WBVar00755193
      WBVar00373749
      WBVar01405462
      WBVar00755194
      WBVar00373750
      WBVar00373751
      WBVar00755195
      WBVar00755196
      WBVar00093334
      WBVar00373752
      WBVar00755197
      WBVar00373753
      WBVar00755198
      WBVar00373754
      WBVar00373755
      WBVar00755199
      WBVar00755200
      WBVar00755201
      WBVar00755202
      WBVar00755203
      WBVar01243097
      WBVar01243099
      WBVar01309266
      WBVar01498940
    Strain: WBStrain00032407
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00024232 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00062275 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00161584 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00131348 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00114754 Pristionchus pacificus From_analysis: OMA
      WBGene00224000 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6765 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g603 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g14358 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g21961 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16694 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4197 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8403 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8157 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1713 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_04850.g19164 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-aqp-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g21403 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01468.g21097 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_19126 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_004731 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10987 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14007 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20299900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_20300400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g5441 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00302875 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-040718-40 Danio rerio From_analysis: OrthoFinder
            EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      SGD:S000001840 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
            PhylomeDB
      SGD:S000003966 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-030131-6461 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2826 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040724-66 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070911-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060503-57 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:636 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:640 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:643 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:16029 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:31976 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:LOC100509620 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1333777 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1314647 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1891066 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2145 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:68433 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:68428 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00000169 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000176 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000175 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013272 Caenorhabditis elegans From_analysis: Panther
      WBGene00000171 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000172 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000173 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000174 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress. Paper_evidence: WBPaper00003343
            WBPaper00013089
            WBPaper00025051
            WBPaper00027009
            WBPaper00027351
            WBPaper00029039
            WBPaper00030907
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Aug 2007 00:00:00
      Automated_description: Enables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:636)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:0060180 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
  Molecular_info: Corresponding_CDS: C01G6.1a
      C01G6.1b
    Corresponding_transcript: C01G6.1a.1
      C01G6.1b.1
      C01G6.1b.2
    Other_sequence (55)
    Associated_feature (22)
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr4772
      Expr1017046
      Expr1030096
      Expr1143468
      Expr2009380
      Expr2027616
    Drives_construct: WBCnstr00012232
      WBCnstr00037690
    Construct_product: WBCnstr00037690
    Microarray_results (37)
    Expression_cluster (293)
    Interaction (19)
  Map_info: Map: II Position: 1.09711 Error: 0.000462
    Positive: Positive_clone: C01G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene