WormBase Tree Display for Gene: WBGene00000170
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| WBGene00000170 | Evidence | Person_evidence | WBPerson548 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C01G6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | aqp-2 | Person_evidence | WBPerson300 | |||||
| Sequence_name | C01G6.1 | ||||||||
| Molecular_name | C01G6.1a | ||||||||
| C01G6.1a.1 | |||||||||
| CE00863 | |||||||||
| C01G6.1b | |||||||||
| CE19664 | |||||||||
| C01G6.1b.1 | |||||||||
| C01G6.1b.2 | |||||||||
| Other_name | CELE_C01G6.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | aqp-2 | ||||||||
| DB_info | Database | AceView | gene | 2J550 | |||||
| WormQTL | gene | WBGene00000170 | |||||||
| WormFlux | gene | WBGene00000170 | |||||||
| NDB | locus_tag | CELE_C01G6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000170|UniProtKB=Q17571 | |||||||
| family | PTHR43829 | ||||||||
| NCBI | gene | 174467 | |||||||
| RefSeq | protein | NM_001393149.1 | |||||||
| NM_001381560.2 | |||||||||
| TREEFAM | TREEFAM_ID | TF313173 | |||||||
| TrEMBL | UniProtAcc | Q17571 | |||||||
| Q7JMQ6 | |||||||||
| UniProt_GCRP | UniProtAcc | Q17571 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aqp | ||||||||
| Allele | WBVar02149947 | ||||||||
| WBVar01696109 | |||||||||
| WBVar01499702 | |||||||||
| WBVar01498435 | |||||||||
| WBVar01604429 | |||||||||
| WBVar01499017 | |||||||||
| WBVar00105277 | |||||||||
| WBVar00755177 | |||||||||
| WBVar00755178 | |||||||||
| WBVar00755179 | |||||||||
| WBVar00755180 | |||||||||
| WBVar00755181 | |||||||||
| WBVar00755182 | |||||||||
| WBVar00755183 | |||||||||
| WBVar00755184 | |||||||||
| WBVar00755185 | |||||||||
| WBVar00755186 | |||||||||
| WBVar00174543 | |||||||||
| WBVar00755187 | |||||||||
| WBVar00755188 | |||||||||
| WBVar02018106 | |||||||||
| WBVar00755189 | |||||||||
| WBVar00755190 | |||||||||
| WBVar00373746 | |||||||||
| WBVar00755191 | |||||||||
| WBVar00373747 | |||||||||
| WBVar00373748 | |||||||||
| WBVar00755192 | |||||||||
| WBVar00755193 | |||||||||
| WBVar00373749 | |||||||||
| WBVar01405462 | |||||||||
| WBVar00755194 | |||||||||
| WBVar00373750 | |||||||||
| WBVar00373751 | |||||||||
| WBVar00755195 | |||||||||
| WBVar00755196 | |||||||||
| WBVar00093334 | |||||||||
| WBVar00373752 | |||||||||
| WBVar00755197 | |||||||||
| WBVar00373753 | |||||||||
| WBVar00755198 | |||||||||
| WBVar00373754 | |||||||||
| WBVar00373755 | |||||||||
| WBVar00755199 | |||||||||
| WBVar00755200 | |||||||||
| WBVar00755201 | |||||||||
| WBVar00755202 | |||||||||
| WBVar00755203 | |||||||||
| WBVar01243097 | |||||||||
| WBVar01243099 | |||||||||
| WBVar01309266 | |||||||||
| WBVar01498940 | |||||||||
| Strain | WBStrain00032407 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00000169 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000176 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00000171 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress. | Paper_evidence | WBPaper00003343 | |||||
| WBPaper00013089 | |||||||||
| WBPaper00025051 | |||||||||
| WBPaper00027009 | |||||||||
| WBPaper00027351 | |||||||||
| WBPaper00029039 | |||||||||
| WBPaper00030907 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Aug 2007 00:00:00 | ||||||||
| Automated_description | Enables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) | ||||
| DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| Molecular_info | Corresponding_CDS | C01G6.1a | |||||||
| C01G6.1b | |||||||||
| Corresponding_transcript | C01G6.1a.1 | ||||||||
| C01G6.1b.1 | |||||||||
| C01G6.1b.2 | |||||||||
| Other_sequence (55) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr4772 | ||||||||
| Expr1017046 | |||||||||
| Expr1030096 | |||||||||
| Expr1143468 | |||||||||
| Expr2009380 | |||||||||
| Expr2027616 | |||||||||
| Drives_construct | WBCnstr00012232 | ||||||||
| WBCnstr00037690 | |||||||||
| Construct_product | WBCnstr00037690 | ||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (293) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | II | Position | 1.09711 | Error | 0.000462 | |||
| Positive | Positive_clone | C01G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
