cima-1 encodes a membrane solute transporter that is a member of the SLC17 family of transporters; CIMA-1 functions postembryonially in epidermal cells to maintain synaptic contacts established during embryogenesis; specifically, CIMA-1 negatively regulates levels of the EGL-15(5A)/FGF receptor isoform to correctly position glia and control epidermal-glia cell adhesion; cima-1 expression begins during embryogenesis and continues through adulthood; in adults, CIMA-1 is mainly found in the epidermis, with some expression also seen in the intestine; a CIMA-1 reporter fusion localizes to lysosomes.
Predicted to enable sialic acid transmembrane transporter activity. Involved in regulation of protein catabolic process and regulation of synapse organization. Located in lysosome. Expressed in hypodermis and intestine.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.