WormBase Tree Display for Gene: WBGene00001135
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| WBGene00001135 | SMap | S_parent | Sequence | ZK512 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | eat-4 | Person_evidence | WBPerson32 | |||||
| Sequence_name | ZK512.6 | ||||||||
| Molecular_name | ZK512.6a | ||||||||
| ZK512.6a.1 | |||||||||
| CE01109 | |||||||||
| ZK512.6b | |||||||||
| CE48482 | |||||||||
| ZK512.6b.1 | |||||||||
| Other_name | not-1 | ||||||||
| vglu-1 | Person_evidence | WBPerson260 | |||||||
| CELE_ZK512.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | eat-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 01 Apr 2010 13:41:12 | WBPerson2970 | Name_change | Other_name | vglu-1 | ||||
| 3 | 30 Apr 2015 13:22:33 | WBPerson4055 | Event | Split_into | WBGene00255687 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eat | ||||||||
| Allele (70) | |||||||||
| Legacy_information | [Leon Avery] Weak Eat. Normal pumps are interspersed with abnormal pumps in which corpus contractions are feeble but long-lasting, and terminal bulb contractions are long-lasting but of normal strength. Phenotype resembles that caused by killing pharyngeal M3 neurons, but is stronger. | ||||||||
| See also ad537, ad572, ad613, ad801 | |||||||||
| [C.elegansII] ad572xri : weak Eat. Normal pumps are interspersed with abnormal pumps in which corpus contractions are feeble but long-lasting, and terminal bulb contractions are long-lasting but of normal strength. Phenotype resembles that caused by killing pharyngeal M3 neurons, but is stronger. Lacks M3-derived IPSPs. Other behavioral defects: Not, Fab,Che, Ttx; possibly general defect in glutametergic neurons.OA6: ad537, ad613, ad801, ad818, ad819, ky5. Cloned: encodes possible transporter protein,"NERD" family (45% identity to rat brain phosphate transporter). eat-4:lacZ expressed in multiple neurons. [Avery 1993; CX; DA; KP] | |||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (56) | |||||||||
| Paralog (58) | |||||||||
| Structured_description | Concise_description | eat-4 encodes an ortholog of the mammalian BNPI vesicular glutamate transporter that affects chemotaxis, feeding, foraging and thermotaxis; eat-4 is expressed in specific neurons, including M3L and M3R which are known to be glutamatergic. | Curator_confirmed | WBPerson363 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in several processes, including glutamatergic synaptic transmission; positive regulation of backward locomotion; and regulation of male mating behavior. Predicted to be located in excitatory synapse and synaptic vesicle membrane. Expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Is an ortholog of human SLC17A7 (solute carrier family 17 member 7) and SLC17A8 (solute carrier family 17 member 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110555 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20151) | ||||
| Molecular_info | Corresponding_CDS | ZK512.6a | |||||||
| ZK512.6b | |||||||||
| Corresponding_transcript | ZK512.6a.1 | ||||||||
| ZK512.6b.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf645465 | ||||||||
| WBsf993585 | |||||||||
| WBsf993586 | |||||||||
| WBsf225528 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (27) | |||||||||
| Construct_product (21) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (181) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | III | Position | 0.173199 | Error | 0.007369 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK512 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 4719 | |||||||
| 6196 | |||||||||
| Multi_point | 1637 | ||||||||
| 1657 | |||||||||
| 1835 | |||||||||
| 1836 | |||||||||
| 1863 | |||||||||
| 2462 | |||||||||
| 2463 | |||||||||
| 4516 | |||||||||
| Pos_neg_data | 7089 | ||||||||
| 7090 | |||||||||
| 7091 | |||||||||
| Reference (153) | |||||||||
| Method | Gene |
