[Robinson N] Defects in migration of cells descended from QR. Positions of a few other cells (BDU, ALM, left coelomocytes) sometimes abnormal. HSN wildtype.
[C.elegansII] mu31 : defects in migration of cells descended from QR. Positions of a few other cells (BDU, ALM, left coelomocytes) sometimes abnormal. HSN wildtype. [CF]
mig-13 encodes a novel single-pass transmembrane protein with a N-terminal signal sequence and two motifs that have been implicated in protein-protein interactions: a CUB domain and a LDL receptor repeat; mig-13 affects the migration and thus the positioning of the Q neuroblasts and their descendants and also the anterior migration of the BDU neuron and may be a component of a global anterior/posterior migration system; a mig-13-gfp translational fusion protein is expressed in embryonic pharyngeal, hypodermal and anterior body neuronal precursors as well as in the cell bodies and axons of a number of neurons in the retrovascular ganglion and the ventral cord; mig-13 localizes to the plasma membrane; mig-13 expression along the A/P axis is restricted by hox gene activity.
Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including QR.a; QR.p; QR.pa; body ganglion; and somatic neurons.