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WormBase Tree Display for Gene: WBGene00002147

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Name Class

WBGene00002147SMapS_parentSequenceC41C4
IdentityVersion1
NameCGC_nameire-1Person_evidenceWBPerson159
Sequence_nameC41C4.4
Molecular_nameC41C4.4a
C41C4.4a.1
CE35836
C41C4.4b
CE45635
C41C4.4b.1
Other_nameCELE_C41C4.4Accession_evidenceNDBBX284602
Public_nameire-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classire
Allele (160)
StrainWBStrain00031637
WBStrain00033316
WBStrain00034062
RNASeq_FPKM (74)
GO_annotation (56)
Ortholog (54)
Structured_descriptionConcise_descriptionire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.Paper_evidenceWBPaper00005036
WBPaper00005044
WBPaper00005432
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA endonuclease activity. Involved in nematode larval development; response to endoplasmic reticulum stress; and response to hypoxia. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway by p53 class mediator. Located in neuronal cell body. Expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and oropharynx cancer. Is an ortholog of human ERN2 (endoplasmic reticulum to nucleus signaling 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
DOID:8557Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
Molecular_infoCorresponding_CDSC41C4.4a
C41C4.4b
Corresponding_CDS_historyC41C4.4:wp111
Corresponding_transcriptC41C4.4a.1
C41C4.4b.1
Other_sequence (32)
Associated_feature (18)
Gene_product_bindsWBsf977530
Experimental_infoRNAi_resultWBRNAi00087898Inferred_automaticallyRNAi_primary
WBRNAi00007958Inferred_automaticallyRNAi_primary
WBRNAi00093264Inferred_automaticallyRNAi_primary
WBRNAi00076208Inferred_automaticallyRNAi_primary
WBRNAi00029717Inferred_automaticallyRNAi_primary
WBRNAi00093258Inferred_automaticallyRNAi_primary
WBRNAi00087883Inferred_automaticallyRNAi_primary
WBRNAi00093173Inferred_automaticallyRNAi_primary
WBRNAi00113279Inferred_automaticallyRNAi_primary
WBRNAi00093267Inferred_automaticallyRNAi_primary
WBRNAi00113050Inferred_automaticallyRNAi_primary
WBRNAi00042277Inferred_automaticallyRNAi_primary
WBRNAi00108778Inferred_automaticallyRNAi_primary
WBRNAi00115389Inferred_automaticallyRNAi_primary
WBRNAi00093262Inferred_automaticallyRNAi_primary
WBRNAi00011832Inferred_automaticallyRNAi_primary
WBRNAi00087897Inferred_automaticallyRNAi_primary
WBRNAi00091963Inferred_automaticallyRNAi_primary
WBRNAi00087878Inferred_automaticallyRNAi_primary
WBRNAi00093265Inferred_automaticallyRNAi_primary
WBRNAi00108488Inferred_automaticallyRNAi_primary
WBRNAi00093081Inferred_automaticallyRNAi_primary
WBRNAi00113584Inferred_automaticallyRNAi_primary
WBRNAi00108405Inferred_automaticallyRNAi_primary
WBRNAi00108395Inferred_automaticallyRNAi_primary
WBRNAi00065378Inferred_automaticallyRNAi_primary
WBRNAi00093257Inferred_automaticallyRNAi_primary
WBRNAi00112535Inferred_automaticallyRNAi_primary
WBRNAi00093171Inferred_automaticallyRNAi_primary
WBRNAi00115393Inferred_automaticallyRNAi_primary
WBRNAi00108779Inferred_automaticallyRNAi_primary
WBRNAi00077192Inferred_automaticallyRNAi_primary
WBRNAi00077400Inferred_automaticallyRNAi_primary
WBRNAi00087896Inferred_automaticallyRNAi_primary
WBRNAi00078678Inferred_automaticallyRNAi_primary
WBRNAi00093106Inferred_automaticallyRNAi_primary
WBRNAi00115391Inferred_automaticallyRNAi_primary
WBRNAi00093266Inferred_automaticallyRNAi_primary
WBRNAi00093098Inferred_automaticallyRNAi_primary
WBRNAi00093263Inferred_automaticallyRNAi_primary
WBRNAi00108406Inferred_automaticallyRNAi_primary
WBRNAi00108777Inferred_automaticallyRNAi_primary
WBRNAi00082072Inferred_automaticallyRNAi_primary
WBRNAi00077402Inferred_automaticallyRNAi_primary
Expr_patternExpr3423
Expr1014693
Expr1031261
Expr1146268
Expr2012815
Expr2031054
Drives_constructWBCnstr00011391
WBCnstr00036417
Construct_productWBCnstr00036417
Microarray_results (21)
Expression_cluster (119)
Interaction (259)
WBProcessWBbiopr:00000030
WBbiopr:00000046
WBbiopr:00000079
WBbiopr:00000121
Map_info (3)
Reference (124)
RemarkSequence connection from [Ron D]. krb 14/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene