WormBase Tree Display for Gene: WBGene00002246
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| WBGene00002246 | SMap | S_parent | Sequence | Y73C8B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lag-2 | Person_evidence | WBPerson320 | |||||
| Sequence_name | Y73C8B.4 | ||||||||
| Molecular_name (3) | |||||||||
| Other_name | sel-3 | ||||||||
| let-461 | |||||||||
| CELE_Y73C8B.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | lag-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lag | ||||||||
| Reference_allele | WBVar00242081 | ||||||||
| Allele (62) | |||||||||
| Possibly_affected_by | WBVar02157826 | ||||||||
| WBVar02157827 | |||||||||
| WBVar02158823 | |||||||||
| Legacy_information | larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus absent, excretory cell absent, often twisted nose (76%). Similar phenotype in q387/Df. NA >6 (some alleles weaker, such as q420, s1486 (pka let-461)) | ||||||||
| Early@20;Mid@15C | |||||||||
| See also s1486 | |||||||||
| [C.elegansII] q387 : larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus absent, excretory cell absent, often twisted nose (76%). Similar phenotype in q387/Df. NA >6: q420 (weaker allele), s1486 (pka let-461), ut103 and ut105 (both Clr). Also gf alleles: n1255, sa37 (pka sel-3,partly suppresses lin-12(gf) mutations.) Cloned: encodes 400 aa membrane protein with similarity to Drosophila Delta and Serrate;transcript present in DTC. [Johnsen and Baillie 1991; Tax et al. 1994; Henderson et al. 1994; MT; JC] | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (20) | |||||||||
| Paralog | WBGene00001103 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001104 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001105 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001107 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001108 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001109 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021525 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021513 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex. | Paper_evidence | WBPaper00001423 | |||||
| WBPaper00002046 | |||||||||
| WBPaper00002635 | |||||||||
| WBPaper00006450 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jan 2005 00:00:00 | ||||||||
| Automated_description | Enables Notch binding activity. Involved in several processes, including maintenance of dauer; regulation of basement membrane organization; and regulation of cell population proliferation. Located in cell projection membrane and neuronal cell body membrane. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neurons; and vulval cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y73C8B.4 | |||||||
| Corresponding_transcript | Y73C8B.4.1 | ||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern (23) | |||||||||
| Drives_construct (50) | |||||||||
| Construct_product | WBCnstr00007161 | ||||||||
| WBCnstr00011838 | |||||||||
| WBCnstr00036363 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (105) | |||||||||
| WBProcess | WBbiopr:00000072 | ||||||||
| Map_info | Map | V | Position | -12.7112 | Error | 0.036939 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T27C3 | |||||||
| Y73C8B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 6125 | |||||||
| 6126 | |||||||||
| Multi_point | 2296 | ||||||||
| 2297 | |||||||||
| 2821 | |||||||||
| 2822 | |||||||||
| 2826 | |||||||||
| 3957 | |||||||||
| 5604 | |||||||||
| Pos_neg_data (16) | |||||||||
| Landmark_gene | |||||||||
| Reference (255) | |||||||||
| Remark | data extracted from Lambie & Kimble 1991 | ||||||||
| [BC Lab] Essential gene. Phenotype of homozygous s1486 at 20C is an early larval lethal. | |||||||||
| [BC Lab] aka sel-3 or lag-2. | |||||||||
| Method | Gene |
