WormBase Tree Display for Gene: WBGene00001086
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WBGene00001086 | SMap | S_parent | Sequence | R13G10 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dpy | ||||||
Reference_allele | WBVar00275305 | ||||||
Allele (91) | |||||||
Legacy_information | rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). NA1. | ||||||
[C.elegansII] rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like Dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). OA5: y57 (weaker allele), y44, y42, y56am, y49 (strongest allele). Cloned: encodes 1469 aa protein with similarities to chromosome structural proteins, specifically localized to X chromosomes in XX but not XO animals. [Plenefisch et al. 1989; Chuang et al. 1994] | |||||||
Strain (6) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (37) | |||||||
Paralog | WBGene00004874 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001830 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00001860 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00003367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004873 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00010306 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00012198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00016172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019087 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00044079 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | dpy-27 encodes an ATP-binding protein that is a homolog of the SMC4 subunit of mitotic condensin; DPY-27, in combination with other proteins including MIX-1, act as a unit to repress X-linked gene expression during hermaphrodite dosage compensation; in XX oocytes and early embryos, DPY-27 exhibits diffuse nuclear localization, but by the 30-cell stage of embryogenesis, DPY-27 specifically localizes to X chromosomes; in XO animals at all stages, DPY-27 remains diffusely nuclear; the sex-specific localization of DPY-27 to X chromosomes is dependent upon wild-type activity of xol-1, as DPY-27 mislocalizes to the X chromosome of XO embryos in a xol-1 mutant background. | Paper_evidence | WBPaper00002061 | |||
WBPaper00005173 | |||||||
WBPaper00005215 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 14 Mar 2006 00:00:00 | ||||||
Automated_description | Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | R13G10.1 | |||||
Corresponding_transcript | R13G10.1.1 | ||||||
Other_sequence | FD516123.1 | ||||||
GO250655.1 | |||||||
SR04997 | |||||||
BXC07601_1 | |||||||
CSC01057_1 | |||||||
MJC03833_1 | |||||||
MJ04686 | |||||||
Associated_feature (15) | |||||||
Gene_product_binds (205) | |||||||
Transcription_factor | WBTranscriptionFactor000139 | ||||||
Experimental_info | RNAi_result (26) | ||||||
Expr_pattern | Expr1534 | ||||||
Expr4351 | |||||||
Expr8708 | |||||||
Expr1013736 | |||||||
Expr1030691 | |||||||
Expr1155578 | |||||||
Expr1200092 | |||||||
Expr2011068 | |||||||
Expr2029305 | |||||||
Drives_construct | WBCnstr00020708 | ||||||
WBCnstr00037089 | |||||||
Construct_product | WBCnstr00016736 | ||||||
WBCnstr00020708 | |||||||
WBCnstr00037089 | |||||||
Regulate_expr_cluster | WBPaper00050193:dpy-27(RNAi)_downregulated_L1 | ||||||
WBPaper00050193:dpy-27(RNAi)_upregulated_L1 | |||||||
Antibody | WBAntibody00000633 | ||||||
WBAntibody00000970 | |||||||
WBAntibody00001231 | |||||||
WBAntibody00001460 | |||||||
WBAntibody00001592 | |||||||
WBAntibody00001731 | |||||||
WBAntibody00001961 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (148) | |||||||
Interaction (183) | |||||||
WBProcess | WBbiopr:00000056 | ||||||
WBbiopr:00000099 | |||||||
Map_info | Map | III | Position | -4.25151 | Error | 0.000409 | |
Well_ordered | |||||||
Positive | Positive_clone | C17A5 | |||||
R13G10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 1612 | |||||
Multi_point | 865 | ||||||
1639 | |||||||
2105 | |||||||
2106 | |||||||
2226 | |||||||
3205 | |||||||
4155 | |||||||
Pos_neg_data | 4706 | ||||||
Reference (135) | |||||||
Method | Gene |