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WormBase Tree Display for Gene: WBGene00006747

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Name Class

WBGene00006747SMapS_parentSequenceCHROMOSOME_X
IdentityVersion3
NameCGC_nameunc-7Person_evidenceWBPerson261
Sequence_nameR07D5.1
Molecular_name (31)
Other_nameunc-12
unc-124Person_evidenceWBPerson621
WBPerson579
CELE_R07D5.1Accession_evidenceNDBBX284606
Public_nameunc-7
DB_infoDatabaseAceViewgeneXP740
WormQTLgeneWBGene00006747
WormFluxgeneWBGene00006747
NDBlocus_tagCELE_R07D5.1
PanthergeneCAEEL|WormBase=WBGene00006747|UniProtKB=Q03412
familyPTHR11893
NCBIgene181608
RefSeqproteinNM_001350352.4
NM_001350353.4
NM_001270327.3
NM_001350355.3
NM_001350356.3
NM_001350358.3
NM_001350354.3
NM_001392896.1
NM_001270326.3
NM_001350357.3
SwissProtUniProtAccQ03412
TrEMBLUniProtAccA0A1T5HUM5
C8JQR8
A0A1T5HUM9
A0A1T5HUM1
A0A1T5HUM6
A0A1T5HUM7
A0A1T5HUM3
C8JQR7
A0A1T5HUN4
UniProt_GCRPUniProtAccQ03412
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
223 Aug 2005 13:14:37WBPerson2970EventAcquires_mergeWBGene00006847
Name_changeOther_nameunc-124
303 Mar 2017 00:18:26WBPerson1983EventAcquires_mergeWBGene00007526
Acquires_mergeWBGene00006847
WBGene00007526
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00142903
Allele (496)
Legacy_informatione5 : moves backward better than forward kinker in forward movement active healthy slightly thin. ES3 ME0. NA5 (e42 e65 (pka unc-12) etc.).
See unc-7.
See also e65
[C.elegansII] e5 : moves backward better than forward, kinker in forward movement, active, healthy, slightly thin. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. e5/Df similar, null phenotype.ES3 ME0. OA>20: e42, e65 (pka unc-12, weaker), bx5::Tc1, st197, mn384 (weaker allele), etc.; also revertants bx5mn369 etc. Cloned: main transcript 2.9 kb, encodes predicted 522 aa membrane protein related to EAT-5, Drosophila passover (26%identity), etc; possible gap junction component. [Starich et al. 1993; Morgan and Sedensky 1994; EH; SP]
[Hecht RM ] cold sensitive, uncoordinated kinker at 11C, WT at 23C, phenotype reversible within hours of temperature shift, throughout development. Dominant interaction with some unc-7 alleles. NA1.
[C.elegansII] hs10cs : uncoordinated at 11C, kinker;WT 23C; phenotype reversible within hoursof temp shift, throughout development. Dominant interaction with some unc-7vt-4alleles. NA1,[HH]
Strain (12)
RNASeq_FPKM (74)
GO_annotation (41)
Ortholog (33)
ParalogWBGene00000488Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
WBGene00001136Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002123Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00002124Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002125Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002127Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002128Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002129Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002130Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002131Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002132Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002133Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002134Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002135Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002136Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002137Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002138Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002139Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002140Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002141Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002142Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002143Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002144Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006749Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionunc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin.Paper_evidence (11)
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSR07D5.1a
R07D5.1b
R07D5.1c
R07D5.1d
R07D5.1e
R07D5.1f
R07D5.1g
R07D5.1h
R07D5.1i
R07D5.1j
Corresponding_transcript (11)
Other_sequence (45)
Associated_feature (33)
Experimental_infoRNAi_result (14)
Expr_pattern (20)
Drives_construct (12)
Construct_productWBCnstr00013477
WBCnstr00014601
WBCnstr00020987
WBCnstr00020988
WBCnstr00021037
WBCnstr00022281
WBCnstr00022773
WBCnstr00033676
WBCnstr00034176
WBCnstr00042489
AntibodyWBAntibody00000520
WBAntibody00001906
WBAntibody00001921
Microarray_results (40)
Expression_cluster (145)
Interaction (84)
Map_infoMapXPosition22.0336Error0.049576
Well_ordered
PositiveInside_rearrmnDf19
mnDp26
Positive_cloneC26D6
R07D5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point (17)
Multi_point (26)
Pos_neg_data (23)
Landmark_gene
ReferenceWBPaper00000031
WBPaper00000162
WBPaper00000214
WBPaper00000513
WBPaper00000608
WBPaper00000724
WBPaper00001028
WBPaper00001281
WBPaper00001455
WBPaper00001686
WBPaper00001747
WBPaper00001854
WBPaper00002006
WBPaper00002020
WBPaper00002440
WBPaper00002505
WBPaper00002950
WBPaper00003024
WBPaper00003184
WBPaper00003300
WBPaper00003309
WBPaper00003394
WBPaper00003617
WBPaper00003792
WBPaper00003828
WBPaper00003954
WBPaper00004182
WBPaper00004217
WBPaper00004649
WBPaper00005862
WBPaper00006103
WBPaper00006494
WBPaper00011032
WBPaper00012429
WBPaper00012640
WBPaper00012735
WBPaper00013608
WBPaper00013816
WBPaper00014310
WBPaper00014761
WBPaper00015083
WBPaper00015160
WBPaper00015440
WBPaper00015442
WBPaper00015628
WBPaper00015652
WBPaper00015879
WBPaper00015930
WBPaper00015943
WBPaper00016024
WBPaper00016119
WBPaper00016248
WBPaper00016538
WBPaper00016942
WBPaper00017219
WBPaper00018354
WBPaper00019359
WBPaper00020954
WBPaper00021851
WBPaper00022069
WBPaper00022253
WBPaper00022432
WBPaper00022725
WBPaper00023302
WBPaper00023590
WBPaper00023627
WBPaper00023675
WBPaper00023688
WBPaper00023755
WBPaper00025465
WBPaper00025689
WBPaper00025986
WBPaper00026083
WBPaper00026145
WBPaper00026693
WBPaper00027055
WBPaper00027661
WBPaper00028277
WBPaper00028502
WBPaper00029115
WBPaper00030343
WBPaper00030757
WBPaper00031030
WBPaper00033075
WBPaper00033138
WBPaper00037203
WBPaper00038318
WBPaper00039151
WBPaper00039235
WBPaper00039259
WBPaper00040432
WBPaper00042443
WBPaper00043292
WBPaper00043409
WBPaper00043908
WBPaper00047129
WBPaper00047675
WBPaper00047676
WBPaper00048044
WBPaper00048285
WBPaper00049295
WBPaper00051925
WBPaper00052792
WBPaper00052797
WBPaper00052819
WBPaper00053608
WBPaper00054278
WBPaper00054762
WBPaper00055514
WBPaper00056066
WBPaper00059213
WBPaper00060250
WBPaper00063648
WBPaper00065757
WBPaper00065804
RemarkCloned, positive rescue by ZK1098 [Byrd D, Jin Y]. krb 14/11/01
MethodGene