e5 : moves backward better than forward kinker in forward movement active healthy slightly thin. ES3 ME0. NA5 (e42 e65 (pka unc-12) etc.).
See unc-7.
See also e65
[C.elegansII] e5 : moves backward better than forward, kinker in forward movement, active, healthy, slightly thin. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. e5/Df similar, null phenotype.ES3 ME0. OA>20: e42, e65 (pka unc-12, weaker), bx5::Tc1, st197, mn384 (weaker allele), etc.; also revertants bx5mn369 etc. Cloned: main transcript 2.9 kb, encodes predicted 522 aa membrane protein related to EAT-5, Drosophila passover (26%identity), etc; possible gap junction component. [Starich et al. 1993; Morgan and Sedensky 1994; EH; SP]
[Hecht RM ] cold sensitive, uncoordinated kinker at 11C, WT at 23C, phenotype reversible within hours of temperature shift, throughout development. Dominant interaction with some unc-7 alleles. NA1.
[C.elegansII] hs10cs : uncoordinated at 11C, kinker;WT 23C; phenotype reversible within hoursof temp shift, throughout development. Dominant interaction with some unc-7vt-4alleles. NA1,[HH]
unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin.
Enables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell.