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WormBase Tree Display for Gene: WBGene00020456

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Name Class

WBGene00020456SMapS_parentSequenceT12B5
IdentityVersion2
NameCGC_namefbxa-60Person_evidenceWBPerson655
Sequence_nameT12B5.10
Molecular_nameT12B5.10
T12B5.10.1
CE20067
Other_nameCELE_T12B5.10Accession_evidenceNDBBX284603
Public_namefbxa-60
DB_infoDatabaseAceViewgene3B560
WormQTLgeneWBGene00020456
WormFluxgeneWBGene00020456
NDBlocus_tagCELE_T12B5.10
PanthergeneCAEEL|WormBase=WBGene00020456|UniProtKB=Q9TZ26
familyPTHR23015
NCBIgene188448
RefSeqproteinNM_064899.4
TREEFAMTREEFAM_IDTF322360
TrEMBLUniProtAccQ9TZ26
UniProt_GCRPUniProtAccQ9TZ26
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
212 Dec 2005 15:18:56WBPerson2970Name_changeCGC_namefbxa-60
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfbxa
Allele (123)
RNASeq_FPKM (74)
GO_annotation (2)
Ortholog (29)
Paralog (222)
Structured_descriptionConcise_descriptionThis gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.Paper_evidenceWBPaper00012854
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2001 00:00:00
Automated_descriptionInvolved in innate immune response. Acts upstream of or within PERK-mediated unfolded protein response.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST12B5.10
Corresponding_transcriptT12B5.10.1
Associated_featureWBsf650830
WBsf226162
WBsf226163
WBsf226164
Experimental_infoRNAi_resultWBRNAi00018634Inferred_automaticallyRNAi_primary
WBRNAi00053179Inferred_automaticallyRNAi_primary
WBRNAi00006629Inferred_automaticallyRNAi_primary
WBRNAi00018627Inferred_automaticallyRNAi_primary
WBRNAi00035500Inferred_automaticallyRNAi_primary
Expr_pattern (3)
Drives_constructWBCnstr00025124
Construct_productWBCnstr00025124
Microarray_results (18)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:all-neurons_embryo_enriched
WBPaper00037950:bodywall-muscle_embryo_enriched
WBPaper00037950:intestine_larva_enriched
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045314:S.aureus-induced_N2
WBPaper00045401:N.parisii_40h_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045809:rsd-2(yp10)_downregulated
WBPaper00045934:wrn-1(gk99)_downregulated
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046509:lin-35(n745)_upregulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00047132:glp-1(ts)-25C_upregulated_skn-1-dependent
WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
WBPaper00048611:MnCl2_downregulated
WBPaper00048952:glucose_repressed
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_downregulated
WBPaper00049334:CE_intestine_enriched
WBPaper00049498:npr-1(ur89)_regulated_5
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049905:Age_variant_expression
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00049954:BPA_upregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050344:ASER-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:intestine_enriched
WBPaper00051257:Levamisole_upregulated
WBPaper00051305:vit-2(ac3)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053020:sid-3(ok973)_upregulated
WBPaper00053020:sta-1(ok587)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053318:Aging_upregulated_mRNA_N2
WBPaper00053318:mir-71(n4115)_upregulated_mRNA
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053771:up_at_3h-NaCl
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00053909:N2_vs_CB4856_upregulated
WBPaper00054410:set-26(tm2467)_downregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056039:efa-6(tm3124)_upregulated
WBPaper00056073:R24_upregulated_nhr-86_dependent
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056167:Cry5B_downregulated
WBPaper00056218:daf-16(mu86)_downregulated_Day7
WBPaper00056284:ints-1(RNAi)_upregulated
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056586:kri-1(ok1251)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057347:nhr-14(tm1473)_upreglated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059191:hsp-16.2p-LIN-29_downregulated
WBPaper00059537:ngn-1(ok2200)_upregulated
WBPaper00059604:fluvastatin_downregulated_N2
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059839:S.maltophilia_regulated
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:CoCl2_6hr_upregulated_N2
WBPaper00060526:plp-1(ok2155)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061527:F58F9.3_11574-R07B7.6
WBPaper00061530:nhr-49(e2144)_upregulated
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00062520:qui-1(db104)_downregulated
WBPaper00062590:Aging_upregulated_coelomocyte
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064871:PA14_upregulated_AWA
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065029:cadmium_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:JU1400_N.ironsii_regulated
WBPaper00065086:JU1400_N.parisii_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065288:mdt-15(tm2182)_upregulated
WBPaper00065331:100nM-ivermectin_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
WBPaper00065835:Day5_vs_Day1_upregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:3_4
WBPaper00065841:30_0
WBPaper00065841:30_3
WBPaper00065841:48_0
WBPaper00065877:rege-1(imm070)_upregulated_OP50
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025099:MA_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00026980:intestine_enriched
WBPaper00027111:eri-1(mg366)_upregulated
WBPaper00027111:rde-3(r459)_downregulated
WBPaper00028482:PA14_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00029437:rde-4_upregulated
WBPaper00032062:age_regulated_genes
WBPaper00034661:AgNPs_downregulated
WBPaper00034739:N2moreDR1350
WBPaper00034739:RIL17moreRIL14
WBPaper00034757:up_by_oxidative_stress
WBPaper00035227:heat_shock_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_D
WBPaper00037704:ABZ_up_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00044091:Bpseudomallei_induced_4h
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00050515:nipi-3(fr4)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00055899:nitroguanidine_regulated
[cgc6390]:Cluster_B
Interaction (175)
Map_infoMapIIIPosition-25.0533Error0.006586
PositivePositive_cloneT12B5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00012854
WBPaper00065331
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene