WormBase Tree Display for Gene: WBGene00017464

WBGene00017464 SMap: S_parent: Sequence: F14D12
  Identity: Version: 2
    Name: CGC_name: sulp-2 Person_evidence: WBPerson2233
      Sequence_name: F14D12.5
      Molecular_name: F14D12.5
        F14D12.5.1
        CE27963
      Other_name: CELE_F14D12.5 Accession_evidence: NDB BX284606
      Public_name: sulp-2
    DB_info: Database: AceView gene XG216
        WormQTL gene WBGene00017464
        WormFlux gene WBGene00017464
        NDB locus_tag CELE_F14D12.5
        Panther gene CAEEL|WormBase=WBGene00017464|UniProtKB=G5EDS5
          family PTHR11814
        NCBI gene 180828
        RefSeq protein NM_076543.7
        TrEMBL UniProtAcc G5EDS5
        UniProt_GCRP UniProtAcc G5EDS5
        OMIM gene 126650
            604943
            605646
            610130
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Jan 2005 16:30:54 WBPerson2970 Name_change: CGC_name: sulp-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sulp
    Allele (50)
    Strain: WBStrain00032065
      WBStrain00032068
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (44)
    Paralog: WBGene00010788 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010789 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012259 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013963 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016945 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018283 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020914 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: sulp-2 encodes one of eight C. elegans members of the sulfate permease family of anion transporters; by homology, SULP-2 is predicted to function as an anion transporter that regulates cellular pH and volume via transmembrane movement of electrolytes and fluids and when expressed in Xenopus oocytes, SULP-2 does exhibit modest uptake of sulfate; a SULP-2::GFP fusion is expressed in the intestine and rectal gland cells, where it localizes to the basolateral membrane and in cephalic and deirid neurons, where it localizes to sensillar endings. Paper_evidence: WBPaper00025075
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Sep 2006 00:00:00
      Automated_description: Enables sulfate transmembrane transporter activity. Predicted to be involved in inorganic anion transmembrane transport and organic anion transport. Located in basolateral plasma membrane and non-motile cilium. Expressed in dopaminergic neurons and intestine. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); and calcium oxalate nephrolithiasis. Is an ortholog of several human genes including SLC26A1 (solute carrier family 26 member 1); SLC26A3 (solute carrier family 26 member 3); and SLC26A4 (solute carrier family 26 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0060744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0060296 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3018)
      DOID:0110498 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0110513 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9359)
      DOID:0080652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10993)
      DOID:13250 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3018)
  Molecular_info: Corresponding_CDS: F14D12.5
    Corresponding_transcript: F14D12.5.1
    Other_sequence: CJC12795_1
    Associated_feature: WBsf670538
      WBsf237387
  Experimental_info: RNAi_result: WBRNAi00000992 Inferred_automatically: RNAi_primary
      WBRNAi00030931 Inferred_automatically: RNAi_primary
      WBRNAi00013264 Inferred_automatically: RNAi_primary
      WBRNAi00044586 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3247
      Expr3259
      Expr1010356
      Expr1148543
      Expr2017113
      Expr2035249
    Drives_construct: WBCnstr00011250
      WBCnstr00011262
      WBCnstr00027278
    Construct_product: WBCnstr00011262
      WBCnstr00027278
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:Cluster_5
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051540:exc-7(csb29);mbl-1(csb30)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00054192:cold-shock_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061340:AIN
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:SMB
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:gtl-1-hum-8_16432
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065074:glna(-)_upregulated
      WBPaper00065841:14_0
      WBPaper00065841:14_1
      WBPaper00065841:14_2
      WBPaper00065841:73_0
      WBPaper00065841:130_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_17
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00027722:Microbacterium_nematophilum_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00034739:N2moreDR1350
      WBPaper00035873:osm-11_regulated
      WBPaper00036286:Pattern_D
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (24)
  Map_info: Map: X Position: -4.46315 Error: 0.008938
    Positive: Positive_clone: F14D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5231
    Pseudo_map_position
  Reference: WBPaper00025075
    WBPaper00035539
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene