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WormBase Tree Display for Gene: WBGene00015437

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Name Class

WBGene00015437SMapS_parentSequenceC04E12
IdentityVersion3
NameCGC_namescrm-3Paper_evidenceWBPaper00029228
Person_evidenceWBPerson1606
Sequence_nameC04E12.7
Molecular_name (3)
Other_nameplsc-1Paper_evidenceWBPaper00030766
Person_evidenceWBPerson1626
CELE_C04E12.7Accession_evidenceNDBBX284605
Public_namescrm-3
DB_infoDatabaseAceViewgene5D836
WormQTLgeneWBGene00015437
WormFluxgeneWBGene00015437
NDBlocus_tagCELE_C04E12.7
PanthergeneCAEEL|WormBase=WBGene00015437|UniProtKB=G5EG07
familyPTHR23248
NCBIgene182212
RefSeqproteinNM_071533.4
TREEFAMTREEFAM_IDTF314939
TrEMBLUniProtAccG5EG07
UniProt_GCRPUniProtAccG5EG07
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:56WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
216 Oct 2006 17:00:28WBPerson2970Name_changeCGC_nameplsc-1
303 May 2007 10:33:07WBPerson2970Name_changeCGC_namescrm-3
Other_nameplsc-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classscrm
Allele (45)
StrainWBStrain00002863
WBStrain00031851
RNASeq_FPKM (74)
GO_annotation00019349
00019350
00019351
00121354
00121355
Ortholog (38)
ParalogWBGene00008681Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00009753Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00011935Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013052Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00014200Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00019531Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00019530Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00235369Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionscrm-3 encodes a putative phospholipid scramblase homologous to humanPLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1);SCRM-3 is expressed in neurons, anal depressor muscle, and occasionallyin body wall muscle cells; however, in apoptotic germline cells, SCRM-3is fully dispensable for normally rapid engulfment and largelydispensable for phosphatidylserine exposure; SCRM-3 does not bind WAH-1in vitro, and scrm-3(tm631) mutants have no obvious phenotype.Paper_evidenceWBPaper00004911
WBPaper00006525
WBPaper00012809
WBPaper00013208
WBPaper00013590
WBPaper00029228
Curator_confirmedWBPerson567
Date_last_updated16 May 2007 00:00:00
Automated_descriptionPredicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be located in plasma membrane. Expressed in body wall musculature and touch receptor neurons. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC04E12.7
Corresponding_CDS_historyC04E12.7:wp188
Corresponding_transcriptC04E12.7.1
Other_sequenceOden_isotig26567
Associated_featureWBsf999601
WBsf999602
WBsf1019356
WBsf233482
WBsf233483
Experimental_infoRNAi_resultWBRNAi00039600Inferred_automaticallyRNAi_primary
WBRNAi00010113Inferred_automaticallyRNAi_primary
WBRNAi00097544Inferred_automaticallyRNAi_primary
Expr_patternChronogram1305
Expr430
Expr4852
Expr5142
Expr8043
Expr1018100
Expr1143701
Expr2015652
Expr2033884
Drives_constructWBCnstr00003109
WBCnstr00004546
WBCnstr00012280
WBCnstr00013073
Microarray_results (14)
Expression_clusterWBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00042194:Tryptophan_downregulated
WBPaper00042194:Tryptophan_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045774:clk-1_upregulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050496:RID_enriched
WBPaper00050496:unc-39(hp701)_regulated
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053909:N2_vs_CB4856_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00059763:neuron_expressed
WBPaper00059839:S.maltophilia_regulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060661:sensory-neuron_enriched
WBPaper00061340:AVL
WBPaper00061340:DVA
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:172183_at-176110_at
WBPaper00061530:nhr-49(e2144)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062590:Aging_upregulated_coelomocyte
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
WBPaper00064716:paraquat_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00066005:RAGA-1_degradation_somatic_downregulated
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00036123:Fluoranthene_regulated
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00046548:dafachronic-acid_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00055899:nitroguanidine_regulated
[cgc6390]:Cluster_A
Interaction (42)
Map_infoMapVPosition-12.0377Error0.017264
PositivePositive_cloneC04E12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00029228
WBPaper00030738
WBPaper00030766
WBPaper00030839
WBPaper00031830
WBPaper00038491
WBPaper00042257
WBPaper00055090
WBPaper00063045
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene