| WBGene00009163 | SMap | S_parent | Sequence | F26E4 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | drsh-1 | Person_evidence | WBPerson490 |
| | | Sequence_name | F26E4.10 |
| | | Molecular_name | F26E4.10a |
| | | | F26E4.10a.1 |
| | | | CE29039 |
| | | | F26E4.10b |
| | | | CE46611 |
| | | | F26E4.10b.1 |
| | | Other_name | CELE_F26E4.10 | Accession_evidence | NDB | BX284601 |
| | | Public_name | drsh-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 23 Jul 2004 12:37:47 | WBPerson1971 | Name_change | CGC_name | drsh-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | drsh |
| | Allele (64) |
| | Strain | WBStrain00036356 |
| | | WBStrain00049716 |
| | | WBStrain00049591 |
| | | WBStrain00050761 |
| | | WBStrain00050760 |
| | | WBStrain00050750 |
| | | WBStrain00054650 |
| | In_cluster | conserved_miRNA_siRNA_cluster |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Contained_in_operon | CEOP1564 |
| | Ortholog (44) |
| | Structured_description | Concise_description | drsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing. | Paper_evidence | WBPaper00024573 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Nov 2004 00:00:00 |
| | | Automated_description | Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be located in nucleus. Predicted to be part of microprocessor complex. Is an ortholog of human DROSHA (drosha ribonuclease III). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F26E4.10a |
| | | F26E4.10b |
| | Corresponding_CDS_history | F26E4.10:wp52 |
| | | F26E4.10:wp62 |
| | | F26E4.10b:wp228 |
| | Corresponding_transcript | F26E4.10a.1 |
| | | F26E4.10b.1 |
| | Other_sequence (24) |
| | Associated_feature | WBsf649519 |
| | | WBsf220147 |
| | | WBsf220148 |
| Experimental_info | RNAi_result | WBRNAi00045638 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003483 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061626 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116443 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00084844 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00045637 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003481 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085189 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00031445 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (5) |
| | Drives_construct | WBCnstr00032409 |
| | Construct_product | WBCnstr00032409 |
| | Regulate_expr_cluster | WBPaper00055896:drsh-1(ok369)_downregulated |
| | | WBPaper00055896:drsh-1(ok369)_upregulated |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032097:CGH-1-associated-mRNA |
| | | WBPaper00037682:sma-2_sma-4_downregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041071:spe-44_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049159:Microwave_upregulated_adult |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050743:elli-1(sam-3)_upregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L4 |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:Neuroblast_AWC_SAAVx |
| | | WBPaper00061340:Neuroblast_M2_M3 |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:dpy-26-B0205.1 |
| | | WBPaper00061527:let-99_22121-B0238.9_11154 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00005124:estrogen_10-5M_regulated |
| | | WBPaper00025032:cluster_53 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00028482:PA14_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031184:acrylamide_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040184:hcf-1up_sir-2.1up_daf-2nc |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_0.2mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053688:E.faecium_upregulated |
| | | [cgc5767]:cluster_49 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (80) |
| | WBProcess | WBbiopr:00000057 |
| | | WBbiopr:00000081 |
| Map_info | Map | I | Position | 3.89894 | Error | 0.002899 |
| | Positive | Positive_clone | F26E4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4838 |
| | | | 4802 |
| | | | 4721 |
| | Pseudo_map_position |
| Reference (22) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
