| WBGene00007772 | SMap | S_parent | Sequence | C27C12 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | egrh-1 | Person_evidence | WBPerson460 |
| | | Sequence_name | C27C12.2 |
| | | Molecular_name | C27C12.2 |
| | | | C27C12.2.1 |
| | | | CE40601 |
| | | Other_name | CELE_C27C12.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | egrh-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 26 Mar 2007 13:57:19 | WBPerson2970 | Name_change | CGC_name | egrh-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | egrh |
| | Allele (58) |
| | Strain | WBStrain00029951 |
| | | WBStrain00051977 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (36) |
| | Paralog | WBGene00003480 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00018990 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00009998 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00043705 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009743 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00012735 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00044651 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | egrh-1 encodes a zinc finger protein that has similarity to the vertebrate EGR (early growth response factor) family of proteins, including the human EGR transcription factors; in C. elegans, EGRH-1 activity is required, non-autonomously in the gut and the somatic gonad, for regulation of oocyte meiotic maturation and ovulation; EGRH-1 is expressed in the somatic gonad, specifically in the gonadal sheath and distal tip cells, and in sperm, as well as in the gut, and other non-gonadal tissues. | Paper_evidence | WBPaper00037082 |
| | | | | Curator_confirmed | WBPerson12884 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 12 Jan 2015 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of oocyte maturation and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Expressed in body wall musculature; hermaphrodite somatic gonadal cell; nervous system; pharynx; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (19) |
| Molecular_info (5) |
| Experimental_info | RNAi_result | WBRNAi00092959 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00029263 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00110186 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076168 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041323 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00110187 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00110188 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00011248 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00114391 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00070166 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr9107 |
| | | Expr1017133 |
| | | Expr1033368 |
| | | Expr1145368 |
| | | Expr2011234 |
| | | Expr2029470 |
| | Drives_construct | WBCnstr00008304 |
| | | WBCnstr00008305 |
| | Construct_product | WBCnstr00008304 |
| | Antibody | WBAntibody00002152 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041071:spe-44_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(+) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051137:Orsay-virus_upregulated_rde-1(ne219) |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00051404:alg-5(ram2)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00034739:TreatmentAffectedGenes |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042574:JU1580_OrsayVirus_upregulated |
| | | WBPaper00044091:Bpseudomallei_induced_12h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (21) |
| | Anatomy_function | WBbtf0409 |
| | | WBbtf0410 |
| | | WBbtf0411 |
| | | WBbtf1061 |
| Map_info | Map | X | Position | 21.4389 | Error | 0.005794 |
| | Positive | Positive_clone | C27C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00027882 |
| | WBPaper00032994 |
| | WBPaper00037082 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| | WBPaper00061738 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
