WormBase Tree Display for Gene: WBGene00006959

WBGene00006959 SMap: S_parent: Sequence: R74
  Identity: Version: 1
    Name: CGC_name: xbp-1 Person_evidence: WBPerson159
      Sequence_name: R74.3
      Molecular_name: R74.3
        R74.3.1
        CE40514
        R74.3.2
      Other_name: CELE_R74.3 Accession_evidence: NDB BX284603
      Public_name: xbp-1
    DB_info: Database: WormQTL gene WBGene00006959
        WormFlux gene WBGene00006959
        NDB locus_tag CELE_R74.3
        Panther gene CAEEL|WormBase=WBGene00006959|UniProtKB=A0FLQ8
          family PTHR46542
        NCBI gene 175541
        RefSeq protein NM_001083177.4
        SwissProt UniProtAcc G5EE07
        UniProt_GCRP UniProtAcc G5EE07
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:44 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: xbp
    Allele (18)
    Possibly_affected_by: WBVar02153517
      WBVar02153518
      WBVar02153519
    Strain: WBStrain00034061
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP3865
    Ortholog (25)
    Structured_description: Concise_description: xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); xbp-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development; loss of xbp-1 activity also results in near-complete loss of myo-2 pharnygeal myosin expression, although pharyngeal muscle is still present. Paper_evidence (5)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Nov 2011 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and response to endoplasmic reticulum stress. Predicted to be located in nucleus. Expressed widely. Is an ortholog of human XBP1 (X-box binding protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:10652
  Modifies_disease_in_annotation: WBDOannot00000237
  Molecular_info: Corresponding_CDS: R74.3
    Corresponding_CDS_history: R74.3:wp166
      R74.3a:wp275
      R74.3c:wp275
    Corresponding_transcript: R74.3.1
      R74.3.2
    Other_sequence (21)
    Associated_feature (16)
    Gene_product_binds: WBsf019101
    Transcription_factor: WBTranscriptionFactor000096
  Experimental_info: RNAi_result (50)
    Expr_pattern: Expr3424
      Expr4095
      Expr7648
      Expr1017530
      Expr1032970
      Expr1155684
      Expr2018089
      Expr2036227
    Drives_construct: WBCnstr00011392
      WBCnstr00012793
      WBCnstr00034070
    Construct_product (11)
    Regulate_expr_cluster: WBPaper00005432:xbp-1(zc12)_downregulated
      WBPaper00005432:xbp-1(zc12)_upregulated
      WBPaper00059175:hlh-17p-XBP-1_downregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
    Antibody: WBAntibody00001600
    Microarray_results (30)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041222:unc-120(st364)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059194:KLF-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:Coelomocyte
      WBPaper00061340:GLR
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:AVB_enriched
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVG_enriched
      WBPaper00061651:AVH_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:SDQ_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064122:vulva_transcriptome
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00065120:body-muscle-transcriptome
      cgc4386_cluster_3_4
      cgc4489_group_24
      WBPaper00025032:cluster_142
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027758:Group_II
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00036130:mir-243_up_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2nc
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction (117)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000046
      WBbiopr:00000050
      WBbiopr:00000079
  Map_info: Map: III Position: -3.69579 Error: 0.005385
    Positive: Positive_clone: R74 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5012
        4785
    Pseudo_map_position
  Reference (132)
  Remark: Sequence connection from [Ron D]. krb 14/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene