| WBGene00004990 | SMap | S_parent | Sequence | T08A9 |
|---|
| Identity (6) |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | spp |
| | Allele (13) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00083250 |
| | | 00083251 |
| | | 00083252 |
| | | 00083253 |
| | Ortholog (25) |
| | Paralog (12) |
| | Structured_description | Concise_description | spp-5 encodes a caenopore, a saposin (B) domain-containing protein that is a member of the saposin-like protein (SAPLIP) superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapore-like proteins; SPP-5 exhibits pore-forming activity and functions as an effector of innate immunity, demonstrating antimicrobial activity against both Gram-positive and Gram-negative bacteria; in addition, SPP-5 is also required for fully normal postembryonic growth and reproduction, likely as a result of its role in killing ingested food, such as E. coli OP50; Northern blot analysisindicates that spp-5 mRNA is expressed constitutively at high levels in the presence of OP50 and a variety of other bacteria; an SPP-5::GFP reporter fusion is expressed exclusively in the intestine; the three-dimensional solution structure of SPP-5 has been determined by NMR spectroscopy revealing five helices, connected by three disulfide bonds, arranged in a folded leaf, the characteristic signature of the SAPLIP family. | Paper_evidence | WBPaper00003435 |
| | | | | | WBPaper00035289 |
| | | | | | WBPaper00035472 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 14 Sep 2010 00:00:00 |
| | | Automated_description | Enables channel activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T08A9.9 |
| | Corresponding_CDS_history | T08A9.9a:wp145 |
| | | T08A9.9b:wp145 |
| | Corresponding_transcript | T08A9.9.1 |
| | Other_sequence | CBC16708_1 |
| | | CBC03827_1 |
| | | CBC16246_1 |
| | | CJC03007_1 |
| | Associated_feature | WBsf654126 |
| | | WBsf237571 |
| Experimental_info | RNAi_result | WBRNAi00001969 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082201 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00018423 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075982 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082195 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082196 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082194 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082203 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr12823 |
| | | Expr1014643 |
| | | Expr1032483 |
| | | Expr1156432 |
| | | Expr2016083 |
| | | Expr2034319 |
| | Drives_construct | WBCnstr00022886 |
| | | WBCnstr00023104 |
| | | WBCnstr00035287 |
| | Construct_product | WBCnstr00022886 |
| | | WBCnstr00035287 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00038118:aak-2(gt33)_downregulated |
| | | WBPaper00038118:stress_downregulated_N2 |
| | | WBPaper00038357:atx-3_regulated_basal |
| | | WBPaper00038357:atx-3_regulated_heat-shock |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY18 |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00045417:19Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046303:P.aeruginosa_downregulated_protein |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048926:miaserin_upregulated_adult-day3 |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049484:elt-2(RNAi)_downregulated_L1 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050234:lin-28(RNAi)_downregulated |
| | | WBPaper00050332:daf-16(RNAi)_downregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_downregulated |
| | | WBPaper00051305:vit-2(ac3)_downregulated |
| | | WBPaper00051388:Glucose-diet_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053792:Ochrobactrum_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053814:OP50_vs_PY79_downregulated_PY79 |
| | | WBPaper00054758:alg-1(gk204)_downregulated |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00056039:ptl-1(ok621)_upregulated |
| | | WBPaper00056139:gut-microbiota_upregulated |
| | | WBPaper00056284:ints-1(RNAi)_upregulated |
| | | WBPaper00056284:ints-2(RNAi)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059604:fluvastatin_upregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_upregulated_N2 |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_downregulated_lpin-1(RNAi) |
| | | WBPaper00059739:hira-1(gk835598)_downregulated_adult |
| | | WBPaper00059739:hira-1(gk835598)_downregulated_L4 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060634:fhod-1(tm2363)_upregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:M.braciatum_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:F54D5.3_7003-F54D5.3_7004 |
| | | WBPaper00061651:Intestine_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062056:lin-35(n745)_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062518:atf-4_regulated |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064502:spe-44(fx110)_downregulated |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064841:tent-5(tm3504)_downregulated_transcript |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064933:L1_secret_protein |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal |
| | | WBPaper00065392:Lb.delbrueckii_downregulated |
| | | WBPaper00065392:Lb.gasseri_downregulated |
| | | WBPaper00065392:Lb.plantarum_downregulated |
| | | WBPaper00065392:Lb.reuteri_downregulated |
| | | WBPaper00065623:20 |
| | | WBPaper00065623:23 |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:3_0 |
| | | WBPaper00065841:3_1 |
| | | WBPaper00065841:3_2 |
| | | WBPaper00065841:3_5 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_PA14 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4386_cluster_1_5 |
| | | cgc4489_group_19 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00035479:glucose_downregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035892:Y.pestis_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00044091:Bpseudomallei_repressed_8h |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | Interaction | WBInteraction000134108 |
| | | WBInteraction000134112 |
| | | WBInteraction000134113 |
| | | WBInteraction000134116 |
| | | WBInteraction000134193 |
| | | WBInteraction000450461 |
| | | WBInteraction000452360 |
| | | WBInteraction000550093 |
| Map_info | Map | X | Position | -1.77287 | Error | 0.00333 |
| | Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00003435 |
| | WBPaper00006437 |
| | WBPaper00024209 |
| | WBPaper00024994 |
| | WBPaper00035289 |
| | WBPaper00035472 |
| | WBPaper00046055 |
| | WBPaper00061547 |
| | WBPaper00064841 |
| | WBPaper00064949 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
