| WBGene00004341 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F11H8 |
| Identity | Version | 1 |
| | Name | CGC_name | rfl-1 | Person_evidence | WBPerson75 |
| | | Sequence_name | F11H8.1 |
| | | Molecular_name (4) |
| | | Other_name | uba-3 | CGC_data_submission |
| | | | cyk-5 |
| | | | CELE_F11H8.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | rfl-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rfl |
| | Allele (30) |
| | Legacy_information | [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis and spindle orientation defects |
| | Strain | WBStrain00003180 |
| | | WBStrain00003181 |
| | | WBStrain00007295 |
| | RNASeq_FPKM (74) |
| | GO_annotation (21) |
| | Ortholog (33) |
| | Paralog | WBGene00000142 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00010882 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006699 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00020184 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00018357 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006735 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006700 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | rfl-1 encodes an ortholog of Uba3p, one subunit of a heterodimeric E1-activatingenzyme that also contains ULA-1 and functions in a Nedd8 ubiquitin-like protein conjugation pathway; RFL-1 activity is required for proper cytokinesis and spindle orientation. | Paper_evidence | WBPaper00004449 |
| | | | | | WBPaper00005108 |
| | | | | | WBPaper00033469 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 06 Jan 2012 00:00:00 |
| | | Automated_description | Predicted to enable NEDD8 activating enzyme activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator and protein neddylation. Located in cytoplasm and nucleus. Expressed in head; tail; and vulval cell. Is an ortholog of human UBA3 (ubiquitin like modifier activating enzyme 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F11H8.1 |
| | Corresponding_CDS_history | F11H8.1:wp102 |
| | Corresponding_transcript | F11H8.1.1 |
| | | F11H8.1.2 |
| | Other_sequence (72) |
| | Associated_feature | WBsf659156 |
| | | WBsf225192 |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern | Chronogram9 |
| | | Chronogram1976 |
| | | Expr5744 |
| | | Expr8724 |
| | | Expr8732 |
| | | Expr1026976 |
| | | Expr1032159 |
| | | Expr1148365 |
| | | Expr2015308 |
| | | Expr2033542 |
| | Drives_construct | WBCnstr00003656 |
| | | WBCnstr00003657 |
| | | WBCnstr00007592 |
| | | WBCnstr00013491 |
| | | WBCnstr00021674 |
| | | WBCnstr00035554 |
| | Construct_product | WBCnstr00007586 |
| | | WBCnstr00007592 |
| | | WBCnstr00013482 |
| | | WBCnstr00013491 |
| | | WBCnstr00021673 |
| | | WBCnstr00021674 |
| | | WBCnstr00035554 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00048785:heat-shock_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AIA |
| | | WBPaper00061527:F54E7.8-orc-5_6376 |
| | | WBPaper00061651:LUA_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_191 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:Resveratrol_regulated_N2 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_17 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(101_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:herm_sex-enriched |
| | Interaction (32) |
| Map_info | Map | III | Position | -0.846313 | Error | 0.00498 |
| | Positive | Positive_clone | F11H8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3854 |
| | | | 3859 |
| Reference (27) |
| Remark | Sequence connection from [Kurz TK, Bowerman BA] |
| | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. |
| Method | Gene |
