WormBase Tree Display for Gene: WBGene00006700
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| WBGene00006700 | SMap | S_parent | Sequence | B0019 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | uba-2 | Person_evidence | WBPerson89 | |||||
| Sequence_name | W02A11.4 | ||||||||
| Molecular_name | W02A11.4 | ||||||||
| W02A11.4.1 | |||||||||
| CE40719 | |||||||||
| Other_name | CELE_W02A11.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | uba-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | uba | ||||||||
| Allele (151) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP1901 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00000142 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004341 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006699 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010882 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020184 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | Paper_evidence | WBPaper00005337 | |||||
| WBPaper00006514 | |||||||||
| WBPaper00023983 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 27 Jan 2005 00:00:00 | ||||||||
| Automated_description | Enables SUMO activating enzyme activity. Involved in several processes, including anterior/posterior pattern specification; nematode larval development; and protein sumoylation. Predicted to be located in cytoplasm. Predicted to be part of SUMO activating enzyme complex. Is an ortholog of human UBA2 (ubiquitin like modifier activating enzyme 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02A11.4 | |||||||
| Corresponding_CDS_history | W02A11.4:wp171 | ||||||||
| W02A11.4a:wp103 | |||||||||
| W02A11.4b:wp103 | |||||||||
| Corresponding_transcript | W02A11.4.1 | ||||||||
| Other_sequence (48) | |||||||||
| Associated_feature | WBsf985680 | ||||||||
| WBsf218636 | |||||||||
| WBsf218637 | |||||||||
| WBsf218638 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr1012814 | ||||||||
| Expr1032783 | |||||||||
| Expr1158086 | |||||||||
| Expr2017696 | |||||||||
| Expr2035834 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (63) | |||||||||
| Map_info | Map | I | Position | 13.9751 | Error | 0.002509 | |||
| Positive | Positive_clone | W02A11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005337 | ||||||||
| WBPaper00006514 | |||||||||
| WBPaper00023983 | |||||||||
| WBPaper00026636 | |||||||||
| WBPaper00028381 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. | ||||||||
| W02A11.4a/b isoforms are no longer valid | Person_evidence | WBPerson1847 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
