WormBase Tree Display for Gene: WBGene00003986

WBGene00003986 SMap: S_parent: Sequence: K05B2
  Identity: Version: 2
    Name: CGC_name: mct-4 Paper_evidence: WBPaper00041876
          Person_evidence: WBPerson3620
      Sequence_name: K05B2.5
      Molecular_name: K05B2.5a
        K05B2.5a.1
        CE34052
        K05B2.5b
        CE39589
        K05B2.5c
        CE39590
        K05B2.5a.2
        K05B2.5b.1
        K05B2.5c.1
      Other_name: pes-22 Person_evidence: WBPerson266
        CELE_K05B2.5 Accession_evidence: NDB BX284606
      Public_name: mct-4
    DB_info: Database: WormQTL gene WBGene00003986
        WormFlux gene WBGene00003986
        NDB locus_tag CELE_K05B2.5
        Panther gene CAEEL|WormBase=WBGene00003986|UniProtKB=H2L0E6
          family PTHR11360
        NCBI gene 180766
        RefSeq protein NM_001383567.1
            NM_001373286.4
            NM_001047802.3
        TrEMBL UniProtAcc H2L0E6
            Q2L6X7
            H2L0E5
        UniProt_GCRP UniProtAcc H2L0E6
        OMIM gene 600682
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 09 Jan 2013 14:40:36 WBPerson2970 Name_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mct
    Allele (147)
    Legacy_information: [C.elegansII] NMK. pes-22:lacZ expressed behind pharyngeal terminal bulb, probably lobes of excretorygl and cell. L1 larvae have apparent gut nuclear staining. Clone UL#161G10, cosmid K05B2. [UL]
    RNASeq_FPKM (74)
    GO_annotation: 00023019
      00023020
      00023021
      00023022
      00112111
      00112112
    Ortholog (57)
    Paralog: WBGene00020168 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015676 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010340 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00021227 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00015273 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008214 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010834 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013353 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017369 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7 and lymphangioleiomyomatosis. Is an ortholog of several human genes including SLC16A1 (solute carrier family 16 member 1); SLC16A7 (solute carrier family 16 member 7); and SLC16A8 (solute carrier family 16 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3319 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10922)
      DOID:0070214 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10922)
  Molecular_info: Corresponding_CDS: K05B2.5a
      K05B2.5b
      K05B2.5c
    Corresponding_CDS_history: K05B2.5:wp99
      K05B2.5:wp153
    Corresponding_transcript: K05B2.5a.1
      K05B2.5a.2
      K05B2.5b.1
      K05B2.5c.1
    Other_sequence (28)
    Associated_feature (16)
  Experimental_info: RNAi_result: WBRNAi00016620 Inferred_automatically: RNAi_primary
      WBRNAi00084916 Inferred_automatically: RNAi_primary
      WBRNAi00001163 Inferred_automatically: RNAi_primary
      WBRNAi00090682 Inferred_automatically: RNAi_primary
      WBRNAi00049968 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr54
      Expr1021530
      Expr1031904
      Expr1153664
      Expr2013458
      Expr2031692
    Drives_construct: WBCnstr00037947
    Construct_product: WBCnstr00037947
    Microarray_results (33)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051311:VGLN-1-interacting
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059471:EGL-43_interacting
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIZ
      WBPaper00061340:ALN
      WBPaper00061340:AVD
      WBPaper00061340:CEP
      WBPaper00061340:Coelomocyte
      WBPaper00061340:DVA
      WBPaper00061340:Excretory_gland
      WBPaper00061340:hmc
      WBPaper00061340:hmc_homolog
      WBPaper00061340:PVP
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:49_0
      WBPaper00065841:60_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      cgc4489_group_3
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:DD_3-day
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053688:E.faecalis_downregulated
      [cgc6390]:Cluster_C
      [cgc6390]:herm_soma-enriched
    Interaction (32)
  Map_info: Map: X Position: -6.21278
    Positive: Positive_clone: K05B2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00062388
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene