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WormBase Tree Display for Gene: WBGene00002056

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Name Class

WBGene00002056SMapS_parentSequenceCHROMOSOME_X
IdentityVersion4
NameCGC_nameifc-2Person_evidenceWBPerson105
WBPerson293
WBPerson260
Sequence_nameM6.1
Molecular_name (19)
Other_nameCel IF C2Accession_evidenceX70832
CelIF c2
ecp-1Paper_evidenceWBPaper00057164
exc-2Person_evidenceWBPerson260
Curator_confirmedWBPerson51134
Date_last_updated07 Aug 2023 16:20:23
CELE_M6.1Accession_evidenceNDBBX284606
Public_nameifc-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
209 Mar 2021 13:49:30WBPerson1983Name_changeOther_nameecp-1
307 Aug 2023 16:03:35WBPerson51134EventAcquires_mergeWBGene00001363
413 Oct 2023 01:37:05WBPerson51134Name_changeCGC_nameifc-2
Other_nameexc-2
Acquires_mergeWBGene00001363
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classifc
Allele (153)
Legacy_information[Buechner M] exc for excretory canal defect. Canals are very short and consist of a series of vacuoles. 100% penetrant. Usually visible by low-power microscopy.
[C.elegansII] rh90 : excretory canal defect. Canals are very short and consist of a series of vacuoles. Luminal coat partly detached, floats in canal.100% penetrant.Usually visible by low-power microscopy. Affects tail spike ??? OA1: rh105. [NJ]
Strain (3)
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (61)
Paralog (12)
Structured_descriptionConcise_descriptionifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength; IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells.Paper_evidenceWBPaper00001981
WBPaper00004761
WBPaper00005492
WBPaper00006137
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to be a structural constituent of cytoskeleton. Involved in post-embryonic digestive tract morphogenesis. Located in cytoplasm and desmosome. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; rectal valve cell; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; ichthyosis (multiple); and palmoplantar keratosis (multiple). Is an ortholog of several human genes including KRT1 (keratin 1); KRT2 (keratin 2); and KRT3 (keratin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (14)
Molecular_infoCorresponding_CDSM6.1a
M6.1b
M6.1c
M6.1d
M6.1e
M6.1f
Corresponding_CDS_historyM6.1a:wp272
M6.1b:wp272
M6.1c:wp272
Corresponding_transcriptM6.1a.1
M6.1a.2
M6.1b.1
M6.1c.1
M6.1d.1
M6.1e.1
M6.1f.1
Other_sequenceCR07924
FD516689.1
CBC09732_1
CJC02211_1
CBC03886_1
CSC00034_1
CRC05750_1
Associated_feature (13)
Experimental_infoRNAi_result (27)
Expr_pattern (17)
Drives_constructWBCnstr00003372
WBCnstr00036488
WBCnstr00042147
WBCnstr00042148
WBCnstr00042149
Construct_productWBCnstr00036488
WBCnstr00042019
WBCnstr00042020
WBCnstr00042147
AntibodyWBAntibody00000563
WBAntibody00002893
WBAntibody00002913
Microarray_results (39)
Expression_clusterWBPaper00029359_1135
WBPaper00029359_1166
WBPaper00029359_1197
WBPaper00029359_1291
WBPaper00029359_1320
WBPaper00029359_1326
WBPaper00029359_1345
WBPaper00029359_1439
WBPaper00029359_1458
WBPaper00029359_1546
WBPaper00029359_1549
WBPaper00029359_1557
WBPaper00029359_1599
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_downregulated_cDNA_24h
WBPaper00033070:Elbe_upregulated
WBPaper00035926:A.hydrophila_regulated
WBPaper00036291:ung-1_regulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00036662:oxidative_modification
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:excretory-cell_larva_enriched
WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038357:atx-3_regulated_basal
WBPaper00038357:atx-3_regulated_heat-shock
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040446:insoluble_protein
WBPaper00040990:PA14_upregulated
WBPaper00043945:MeHg_downregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044037:eat-2_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045521:Gender_Neutral
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046012:tdp-1(ok803)_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00047132:skn-1(RNAi)_downregulated
WBPaper00048644:germline_enriched
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049018:swsn-2.2(RNAi)_upregulated
WBPaper00049217:TCER-1_downregulated
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049417:B.animalis_upregulated
WBPaper00049498:npr-1(ur89)_regulated_7
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050686:glp-1(e2141)_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:ash-2(RNAi)_regulated_intestine
WBPaper00051039:intestine_enriched
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051352:Long-Term-Association-Memory_downregulated
WBPaper00051461:pig-1(gm344)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:female_vs_male_downregulated
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:ptl-1(ok621)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056290:hsp-6(mg585)_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056619:CEPsh_enriched
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056900:PID-3_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059334:SACY-1_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Excretory_cell
WBPaper00061340:hyp1V_and_ant_arc_V
WBPaper00061340:hyp1_hyp2
WBPaper00061340:Rectal_gland
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061405:S.aureus_upregulated_starvation
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:C18B2.5-haf-4_181
WBPaper00061527:gst-26-pho-1_10767
WBPaper00061651:Rectal_gland_enriched
WBPaper00061818:ELKS-1_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00063976:micu-1(bon20)_upregulated
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064505:tamoxifen_downregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064728:cpl-1(W32AY35A)_upregulated
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064992:Capsaicin_downregulated
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_depleted
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065392:Lb.reuteri_upregulated
WBPaper00065392:Lb.rhamnosus_upregulated
WBPaper00065392:P.pentosaceus_upregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_4
WBPaper00065841:11_3
WBPaper00065841:15_0
WBPaper00065841:26_1
WBPaper00065841:27_0
WBPaper00065841:30_0
WBPaper00065841:30_3
WBPaper00065841:30_4
WBPaper00065841:34_0
WBPaper00065841:34_1
WBPaper00065841:79_1
WBPaper00065841:132_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066085:hda-3(ok1991)_upregulated
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
cgc4386_cluster_1_3
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00028474:dys-1_upregulated
WBPaper00028789:PA14_vs_OP50_upregulated_8hr
WBPaper00031060:2-deoxy-D-glucose_upregulated
WBPaper00034661:AgNPs_downregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00037113:Diazinon_16C_regulated
WBPaper00037695:LD_DD_6-day
WBPaper00038060:SUMO-1_downregulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00038462:aging_downregulated
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040963:Q50_down
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_L4_intestine
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045263:ProLongevity-mtROS_downregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_downregulated
[cgc6390]:Cluster_C
Interaction (77)
Map_infoMapXPosition-19.5186Error0.005743
PositivePositive_cloneM6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4971
Pseudo_map_position
Reference (41)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene