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WormBase Tree Display for Gene: WBGene00002054

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Name Class

WBGene00002054EvidenceCGC_data_submission
SMapS_parentSequenceF10C1
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classifb
Allele (87)
StrainWBStrain00036909
RNASeq_FPKM (74)
GO_annotation (19)
Contained_in_operonCEOP2220
Ortholog (61)
Paralog (12)
Structured_descriptionConcise_descriptionifb-2 encodes an intermediate filament protein; IFB-2 is expressed exclusively in the intestine and functions as a structural component of the intestinal terminal web; within the terminal web, IFB-2 localizes to a discrete substructure known as the endotube.Paper_evidenceWBPaper00001981
WBPaper00004761
WBPaper00040246
WBPaper00040999
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated31 Mar 2014 00:00:00
Automated_descriptionPredicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Located in apical cortex; cell junction; and terminal web. Expressed in intestine. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
DOID:0070296Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
DOID:0080299Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
Molecular_infoCorresponding_CDSF10C1.7a
F10C1.7c
F10C1.7e
Corresponding_CDS_historyF10C1.7b:wp86
F10C1.7d:wp86
Corresponding_transcriptF10C1.7a.1
F10C1.7c.1
F10C1.7e.1
Other_sequence (11)
Associated_featureWBsf644222
WBsf657615
WBsf716987
WBsf987950
WBsf987951
WBsf221327
Experimental_infoRNAi_resultWBRNAi00062660Inferred_automaticallyRNAi_primary
WBRNAi00030750Inferred_automaticallyRNAi_primary
WBRNAi00044220Inferred_automaticallyRNAi_primary
WBRNAi00007219Inferred_automaticallyRNAi_primary
WBRNAi00062659Inferred_automaticallyRNAi_primary
WBRNAi00062648Inferred_automaticallyRNAi_primary
WBRNAi00113732Inferred_automaticallyRNAi_primary
WBRNAi00065111Inferred_automaticallyRNAi_primary
WBRNAi00062647Inferred_automaticallyRNAi_primary
WBRNAi00113728Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00000753
WBCnstr00008798
WBCnstr00008801
WBCnstr00036490
Construct_productWBCnstr00000753
WBCnstr00009121
WBCnstr00036490
WBCnstr00038174
WBCnstr00038430
AntibodyWBAntibody00000056
WBAntibody00000795
WBAntibody00002280
Microarray_results (39)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035926:A.hydrophila_regulated
WBPaper00035963:S.aureus_1h_downregulated
WBPaper00035963:S.aureus_8h_downregulated
WBPaper00035963:S.aureus_24h_upregulated
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00038357:atx-3_regulated_heat-shock
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040446:insoluble_protein
WBPaper00040990:PA14_upregulated
WBPaper00043945:MeHg_downregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044037:eat-2_upregulated
WBPaper00044128:daf-2(e1370)_upregulated
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044638:daf-2(e1370)rsks-1(ok1255)_regulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045314:S.aureus-induced_N2
WBPaper00045401:N.parisii_64h_upregulated
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045420:fertilization_upregulated_transcript
WBPaper00045486:starvation_upregulated
WBPaper00045520:V.alginolyticus_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00045861:set-2(ok952)_upregulated
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046121:endoderm_unique
WBPaper00046446:rapid-synthesized_AgingAdult
WBPaper00046446:slow-synthesized_YoungAdult
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048644:germline_enriched
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049334:CE_intestine_enriched
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049498:npr-1(ur89)_regulated_1
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050599:nicotine(0.01mM)_upregulated
WBPaper00050599:nicotine(1mM)_upregulated
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:ash-2(RNAi)_regulated_intestine
WBPaper00051039:intestine_enriched
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00051538:micro-gavity_downregulated_protein
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:female_vs_male_downregulated
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053657:N2_M.humicola-infection_24hr
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:ptl-1(ok621)_downregulated
WBPaper00056039:ptrn-1(tm5597)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_downregulated_Day7
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056474:ivermectin-resistent_vs_N2_downregulated_protein
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOST-1_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057288:Cold_downregulated_protein
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058711:wdr-5(ok1417)_downregulated
WBPaper00058801:ceh-60(lst466)_upregulated_protein
WBPaper00058948:PA14_downregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060871:M.humicola-extract_24h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:C18B2.5-haf-4_181
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062456:doxycycline_upregulated_N2_transcript
WBPaper00062554:MAGU-2_interacting
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064624:iHg-induced_aggregome
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064789:Day12_vs_Day1_upregulated_neuron
WBPaper00064871:PA14_upregulated_AWA
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065392:Lb.plantarum_upregulated
WBPaper00065392:Lb.reuteri_upregulated
WBPaper00065392:Lb.rhamnosus_upregulated
WBPaper00065392:P.pentosaceus_upregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_0
WBPaper00065841:3_1
WBPaper00065841:3_2
WBPaper00065841:3_4
WBPaper00065841:3_5
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
cgc4386_cluster_1_3
cgc4489_group_3
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025099:NI_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00033101:spr-5_regulated
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035892:Y.pestis_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00038060:SUMO-1_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045263:ProLongevity-mtROS_downregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00053236:Starvation_regulated_N2
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc6390]:Cluster_B
Interaction (109)
Map_infoMapIIPosition-0.954772Error0.000663
PositivePositive_cloneF10C1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (34)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene