WormBase Tree Display for Gene: WBGene00001690

WBGene00001690 Evidence: Paper_evidence: WBPaper00003717
  SMap: S_parent: Sequence: R08B4
  Identity: Version: 1
    Name: CGC_name: grd-1 Person_evidence: WBPerson83
      Sequence_name: R08B4.1
      Molecular_name: R08B4.1
        R08B4.1.1
        CE34080
        R08B4.1.2
      Other_name: CELE_R08B4.1 Accession_evidence: NDB BX284606
      Public_name: grd-1
    DB_info: Database: AceView gene XL733
        WormQTL gene WBGene00001690
        WormFlux gene WBGene00001690
        NDB locus_tag CELE_R08B4.1
        Panther gene CAEEL|WormBase=WBGene00001690|UniProtKB=Q7YXC8
          family PTHR46706
        NCBI gene 181300
        RefSeq protein NM_001029672.3
        TrEMBL UniProtAcc Q21835
        UniProt_GCRP UniProtAcc Q21835
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: grd
    Allele (93)
    Strain: WBStrain00035810
    RNASeq_FPKM (74)
    GO_annotation (3)
    Ortholog (42)
    Paralog (24)
    Structured_description: Concise_description: grd-1 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Ground domain, an extended region of low-complexitysequence, and a Hint/Hog domain; GRD-1 is expressed in rectal cells; theHint/Hog domain is predicted to cut GRD-1 into two halves and thencovalently link cholesterol to the C-terminus of the Ground domain; theGround domain is predicted to form a cysteine-crosslinked proteininvolved in intercellular signalling, and it has subtle similarity tothe N-terminal Hedge domain of HEDGEHOG proteins; GRD-1 is weaklyrequired for normal molting; GRD-1 is also required for normal growth tofull size, cuticle adhesion, and male tail development; all of theserequirements may reflect common defects in cholesterol-dependenthedgehog-like signalling or in vesicle trafficking. Paper_evidence: WBPaper00003717
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R08B4.1
    Corresponding_CDS_history: R08B4.1:wp52
      R08B4.1:wp83
      R08B4.1:wp101
      R08B4.1b:wp272
    Corresponding_transcript: R08B4.1.1
      R08B4.1.2
    Other_sequence (17)
    Associated_feature: WBsf648520
      WBsf648521
      WBsf1023814
  Experimental_info: RNAi_result: WBRNAi00076990 Inferred_automatically: RNAi_primary
      WBRNAi00077015 Inferred_automatically: RNAi_primary
      WBRNAi00051525 Inferred_automatically: RNAi_primary
      WBRNAi00017576 Inferred_automatically: RNAi_primary
      WBRNAi00111006 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr633
      Expr4417
      Expr1026738
      Expr1031009
      Expr1155201
      Expr2012231
      Expr2030467
    Drives_construct: WBCnstr00011978
      WBCnstr00012457
      WBCnstr00036766
    Construct_product: WBCnstr00036766
    Microarray_results (27)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053154:human-amyloid-beta_tau_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Hypodermis
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ_parent
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:col-128-cdh-10_9234
      WBPaper00061527:mlt-9_22518-F33D4.6_14044
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065841:33_0
      WBPaper00065841:33_1
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_8
      WBPaper00026980:intestine_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00039866:SAM_daf-19_downregulated
      WBPaper00040116:pRJ-FR.5_down_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00041207:CE_dauer_down
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction: WBInteraction000114598
      WBInteraction000114599
      WBInteraction000114607
      WBInteraction000173618
      WBInteraction000237583
    WBProcess: WBbiopr:00000123
  Map_info: Map: X Position: 2.85852 Error: 0.000413
    Positive: Positive_clone: R08B4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4384
        4421
        5511
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene