WormBase Tree Display for Gene: WBGene00001149

WBGene00001149 SMap: S_parent: Sequence: K02A4
  Identity: Version: 2
    Name: CGC_name: bcat-1
      Sequence_name: K02A4.1
      Molecular_name: K02A4.1
        K02A4.1.1
        CE03457
      Other_name: ECA39 Accession_evidence: EMBL U21550
        eca-39
        CELE_K02A4.1 Accession_evidence: NDB BX284606
      Public_name: bcat-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 07 Jul 2004 10:08:30 WBPerson1971 Name_change: CGC_name: bcat-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bcat
    Allele (46)
    Strain: WBStrain00001179
      WBStrain00001764
      WBStrain00047484
    Component_of_genotype (3)
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (45)
    Paralog: WBGene00012855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: bcat-1 encodes a branched-chain amino acid aminotransferase that, by homology, is predicted to catalyze the first reaction in the catabolism of essential branched-chain amino acids such as leucine, isoleucine, and valine; in C. elegans, large-scale RNA-mediated interference (RNAi) screens indicate that bcat-1 activity is required for embryonic and larval development. Paper_evidence: WBPaper00004424
            WBPaper00004651
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Apr 2007 00:00:00
      Automated_description: Predicted to enable branched-chain-amino-acid transaminase activity. Involved in branched-chain amino acid catabolic process; embryo development; and nematode larval development. Acts upstream of or within determination of adult lifespan. Located in mitochondrion. Is an ortholog of human BCAT2 (branched chain amino acid transaminase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K02A4.1
    Corresponding_transcript: K02A4.1.1
    Other_sequence (65)
    Associated_feature: WBsf717381
      WBsf717382
      WBsf982257
      WBsf1007453
      WBsf1007454
      WBsf1007455
      WBsf1024141
      WBsf236520
  Experimental_info: RNAi_result: WBRNAi00000799 Inferred_automatically: RNAi_primary
      WBRNAi00027821 Inferred_automatically: RNAi_primary
      WBRNAi00113698 Inferred_automatically: RNAi_primary
      WBRNAi00016424 Inferred_automatically: RNAi_primary
      WBRNAi00090701 Inferred_automatically: RNAi_primary
      WBRNAi00113697 Inferred_automatically: RNAi_primary
      WBRNAi00049654 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1431
      Chronogram1998
      Expr6303
      Expr9526
      Expr12614
      Expr1016785
      Expr1030730
      Expr1153380
      Expr2009579
      Expr2027816
    Drives_construct: WBCnstr00002071
      WBCnstr00004210
      WBCnstr00022449
      WBCnstr00037065
      WBCnstr00038736
    Construct_product: WBCnstr00014091
      WBCnstr00022449
      WBCnstr00037065
      WBCnstr00038736
    Regulate_expr_cluster: WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
    Microarray_results (24)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00029359_1145
      WBPaper00029359_1197
      WBPaper00029359_1208
      WBPaper00029359_1225
      WBPaper00029359_1242
      WBPaper00029359_1291
      WBPaper00029359_1367
      WBPaper00029359_1483
      WBPaper00029359_1494
      WBPaper00029359_1546
      WBPaper00029359_1561
      WBPaper00029359_1692
      WBPaper00032425:down_in_zfp-1
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00035073:mitochondria_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044128:DietaryRestriction_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00046121:endoderm_unique
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046741:Garlic-Extract_upregulated_mRNA
      WBPaper00046795:starvation_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049083:post-dauer-development_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052987:UV_downregulated_xpc-1;csb-1
      WBPaper00053254:hsp-90(RNAi)_downregulated_protein
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060006:nfyb-1(cu13)_upregulated_transcript
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061405:S.aureus_upregulated_starvation
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061651:Gonadal_sheath_cell_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062156:jmjd-5(zr1234)_upregulated_germline
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064841:tent-5(tm3504)_upregulated_protein
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_1_2
      cgc4489_group_3
      WBPaper00025032:cluster_23
      WBPaper00025032:cluster_54
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040426:CYE-1_CDK-2AF_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00053688:E.faecium_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:Cluster_C
      [cgc6390]:herm_soma-enriched
    Interaction (153)
  Map_info: Map: X Position: 8.78096
    Positive: Positive_clone: K02A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene