| WBGene00000858 | SMap | S_parent | Sequence | W01B6 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cwn-2 | Person_evidence | WBPerson1157 |
| | | Sequence_name | W01B6.1 |
| | | Molecular_name | W01B6.1 |
| | | | W01B6.1.1 |
| | | | CE03753 |
| | | Other_name | Wnt-2 |
| | | | CELE_W01B6.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | cwn-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cwn |
| | Allele (30) |
| | Legacy_information | [C.elegansII] NMK. 1.5 kb transcript, most abundant in embryo, encodes predicted 362 aa Wnt homolog. [Shackleford et al. 1993; CF] |
| | | [Shivakumar S, Jongeward G] C. elegans wnt homolog. originally isolated as cm9h7. Accession number cwn-2 mRNA X72943 |
| | Strain (21) |
| | RNASeq_FPKM (74) |
| | GO_annotation (66) |
| | Ortholog (48) |
| | Paralog | WBGene00000857 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | cwn-2 encodes one of five C. elegans Wnt signaling molecules that is homologous to mammalian Wnt5; cwn-2 is required for proper placement of the nerve ring and anterior cells along the anterior/posterior axis; cwn-2 also acts redundantly to specify cell fates during vulval development; CWN-2 appears to be required at the time of nerve ring development (comma stage of embryogenesis) for nerve ring placement and likely functions as a signaling ligand for receptors, such as CAM-1, that regulate axon guidance of the SIA and SIB neurons that plays a role in nerve ring placement; CWN-2, along with LIN-17, CAM-1, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; in embryos at the comma stage, a cwn-2::gfp reporter is expressed in the intestine and in pharyngeal muscle; in larvae and adults, cwn-2::gfp is seen in the intestine, pharynx, anterior body wall muscle, vulva and SMD head neurons. | Paper_evidence (5) |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 17 Apr 2012 00:00:00 |
| | | Automated_description | Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including neuroblast migration; neuron migration; and pattern specification process. Predicted to be located in extracellular space. Expressed in several structures, including P5.ppp; P7.paa; RME; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant Robinow syndrome 1; endometrial carcinoma; and germ cell cancer (multiple). Is an ortholog of human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12784) |
| | | DOID:1911 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) |
| | | DOID:0060766 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12784) |
| | | DOID:3307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) |
| | | DOID:127 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16265) |
| | | DOID:0060774 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) |
| Molecular_info | Corresponding_CDS | W01B6.1 |
| | Corresponding_transcript | W01B6.1.1 |
| | Other_sequence (34) |
| | Associated_feature | WBsf660548 |
| | | WBsf997547 |
| | | WBsf997548 |
| | | WBsf1018041 |
| | | WBsf1018042 |
| | | WBsf228924 |
| Experimental_info | RNAi_result (18) |
| | Expr_pattern (16) |
| | Drives_construct (16) |
| | Construct_product (15) |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00035197:fer-1_downregulated |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046121:endoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050843:sesamin_downregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_enriched |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057068:ints-4(RNAi)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:mc3 |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:Pharyngeal_intestinal_valve |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:F08G12.1_2283-cst-1_319 |
| | | WBPaper00061651:M5_enriched |
| | | WBPaper00061651:SMD_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062590:Aging_upregulated_body-wall-muscle |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064532:pals-22(jy3)_downregulated |
| | | WBPaper00064539:nhr-114(gk849)_downregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065623:45 |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:96_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:124_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065841:135_0 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(122_min) |
| | Interaction (134) |
| | Anatomy_function | WBbtf0799 |
| | | WBbtf0800 |
| | | WBbtf0801 |
| | WBProcess | WBbiopr:00000023 |
| | | WBbiopr:00000073 |
| Map_info | Map | IV | Position | 4.48175 | Error | 0.001015 |
| | Positive | Positive_clone | B0555 |
| | | | W01B6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (80) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
