WormBase Tree Display for Gene: WBGene00000857
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| WBGene00000857 | SMap | S_parent | Sequence | K10B4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cwn-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | K10B4.6 | ||||||||
| Molecular_name | K10B4.6a | ||||||||
| K10B4.6a.1 | |||||||||
| CE12072 | |||||||||
| K10B4.6b | |||||||||
| Other_name | Wnt-1 | Accession_evidence | EMBL | X72942 | |||||
| X72941 | |||||||||
| CELE_K10B4.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cwn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cwn | ||||||||
| Allele (39) | |||||||||
| Legacy_information | [Shivakumar S, Jongeward G] early embryonic arrest. psoralen screen for lethals rescued by transgene including R180. encodes CeWnt1, a C. elegans wnt homolog. | ||||||||
| [C.elegansII] mu109 : embryonic lethal, early arrest as disorganized embryo at 2-3 fold stage; allele obtained by psoralen screen for lethals rescued by cwn-1 transgene. OA1: mu110.Cloned: 1.4 kb transcript, transspliced; most abundant in embryo; encodes 372 aa Wnt homolog[Shackleford et al. 1993; CF] | |||||||||
| Strain (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000858 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cwn-1 encodes one of five C. elegans Wnt signaling ligands; during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages. | Paper_evidence | WBPaper00001170 | |||||
| WBPaper00001743 | |||||||||
| WBPaper00025032 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 27 Apr 2009 00:00:00 | ||||||||
| Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in extracellular space. Expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism and endometrial carcinoma. Is an ortholog of human WNT4 (Wnt family member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||||
| DOID:0111526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||||||
| Molecular_info | Corresponding_CDS | K10B4.6a | |||||||
| Corresponding_CDS_history | K10B4.6b:wp247 | ||||||||
| Corresponding_transcript | K10B4.6b | ||||||||
| K10B4.6a.1 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf649804 | ||||||||
| WBsf986332 | |||||||||
| WBsf1011348 | |||||||||
| WBsf222564 | |||||||||
| WBsf222565 | |||||||||
| WBsf222566 | |||||||||
| WBsf222567 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (20) | |||||||||
| Construct_product (15) | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (67) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000023 | |||||||||
| WBbiopr:00000073 | |||||||||
| Map_info | Map | II | Position | -15.9676 | Error | 0.013997 | |||
| Positive | Positive_clone | K10B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| R180 | |||||||||
| Mapping_data | Multi_point | 4244 | |||||||
| Pseudo_map_position | |||||||||
| Reference (89) | |||||||||
| Remark | replaces int-12, pcr clone isolated by Sasha Kamb. the accession numbers for these genes X72941 cwn-1 mRNA X72942 cwn-1 gene (introns included) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
