| WBGene00000554 | Evidence | Paper_evidence | WBPaper00005483 |
|---|
| SMap | S_parent | Sequence | F55C10 |
| Identity | Version | 1 |
| | Name | CGC_name | cnb-1 | Person_evidence | WBPerson746 |
| | | Sequence_name | F55C10.1 |
| | | Molecular_name | F55C10.1a |
| | | | F55C10.1a.1 |
| | | | CE32679 |
| | | | F55C10.1b |
| | | | CE47380 |
| | | | F55C10.1b.1 |
| | | Other_name | CELE_F55C10.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | cnb-1 |
| | DB_info | Database | AceView | gene | 5L857 |
| | | | WormQTL | gene | WBGene00000554 |
| | | | WormFlux | gene | WBGene00000554 |
| | | | NDB | locus_tag | CELE_F55C10.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000554|UniProtKB=G5EDN6 |
| | | | | family | PTHR45942 |
| | | | NCBI | gene | 179572 |
| | | | RefSeq | protein | NM_001269389.2 |
| | | | | | NM_001269388.2 |
| | | | SwissProt | UniProtAcc | G5EDN6 |
| | | | TrEMBL | UniProtAcc | H9G2Y1 |
| | | | UniProt_GCRP | UniProtAcc | G5EDN6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cnb |
| | Allele (25) |
| | Strain | WBStrain00023526 |
| | | WBStrain00036229 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog (40) |
| | Paralog | WBGene00003941 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00009260 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00014109 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019108 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020192 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | cnb-1 encodes an ortholog of calcineurin B, the regulatory subunit of the protein phosphatase 2B with four EF-hand motifs for calcium binding, that binds TAX-6 (a calcineurin A ortholog) in a calcium-dependent manner; CNB-1 binds calcium, enhances the phosphatase activity of TAX-6 in vitro, promotes transcription of rcn-1, and is required for normal cuticle formation, sperm morphology, and brood size; cnb-1 null mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1 and atg-7. | Paper_evidence | WBPaper00005483 |
| | | | | | WBPaper00005829 |
| | | | | | WBPaper00032986 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 29 Apr 2009 00:00:00 |
| | | Automated_description | Enables calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Expressed in several structures, including germ line; gonad; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Is an ortholog of human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9317) |
| | | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9317) |
| Molecular_info (5) |
| Experimental_info | RNAi_result | WBRNAi00048457 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00003250 |
| | | WBCnstr00010474 |
| | | WBCnstr00010565 |
| | | WBCnstr00037457 |
| | Construct_product (3) |
| | Regulate_expr_cluster | WBPaper00027022:cnb-1(jh103)_downregulated |
| | | WBPaper00027022:cnb-1(jh103)_upregulated |
| | Antibody | WBAntibody00000561 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040990:PA14_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049495:starvation-refeeding_regulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050496:RID_enriched |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AFD |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:PVP |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:Y37D8A.16-F54D1.6_15313 |
| | | WBPaper00061651:ADE_enriched |
| | | WBPaper00061651:AQR_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061651:PVD_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064992:Capsaicin_downregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_5_5 |
| | | cgc4489_group_6 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00050538:Fasting_upregulated_cholesterol-dependent |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (71) |
| Map_info | Map | V | Position | 3.07846 | Error | 0.000352 |
| | Positive | Positive_clone | F55C10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4230 |
| | Pseudo_map_position |
| Reference (48) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
