WormBase Tree Display for Gene: WBGene00000282

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WBGene00000282	SMap	S_parent	Sequence	R01E6
	Identity	Version	1
		Name (5)
		DB_info	Database	AceView	gene	XO161
				WormQTL	gene	WBGene00000282
				WormFlux	gene	WBGene00000282
				NDB	locus_tag	CELE_R01E6.3
				Panther	gene	CAEEL\|WormBase=WBGene00000282\|UniProtKB=Q21614
					family	PTHR18952
				NCBI	gene	181478
				RefSeq	protein	NM_077864.6
						NM_077863.9
				TrEMBL	UniProtAcc	Q8WQD8
						Q21614
				UniProt_GCRP	UniProtAcc	Q21614
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:20	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	cah
		Allele (38)
		RNASeq_FPKM (74)
		GO_annotation (11)
		Ortholog (32)
		Paralog	WBGene00000279	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000280	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000281	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000283	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000284	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
		Structured_description	Concise_description	cah-4 encodes a carbonic anhydrase homolog, which is rather divergent from other such homologs in C. elegans (with at most 38% identity to any other carbonic anhydrase, in or out of C. elegans); it is individually dispensable for viability and for grossly normal postembryonic morphology, and thus may have a more subtle biological function than the basic cytoprotective functions expected for carbonic anhydrases.	Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Enables carbonate dehydratase activity. Involved in small molecule metabolic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; enteric muscle; excretory cell; rectal muscle; and somatic nervous system. Is an ortholog of several human genes including CA1 (carbonic anhydrase 1); CA3 (carbonic anhydrase 3); and CA5A (carbonic anhydrase 5A).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Modifies_disease	DOID:11723
	Modifies_disease_in_annotation	WBDOannot00000425
		WBDOannot00000430
		WBDOannot00000431
	Molecular_info	Corresponding_CDS	R01E6.3a
			R01E6.3b
		Corresponding_CDS_history	R01E6.3:wp65
		Corresponding_transcript	R01E6.3a.1
			R01E6.3b.1
		Other_sequence (37)
		Associated_feature	WBsf648678
			WBsf716638
			WBsf1007641
			WBsf1024250
			WBsf236581
			WBsf236582
			WBsf236583
			WBsf236584
	Experimental_info	RNAi_result	WBRNAi00000716	Inferred_automatically	RNAi_primary
			WBRNAi00027423	Inferred_automatically	RNAi_primary
			WBRNAi00077519	Inferred_automatically	RNAi_primary
			WBRNAi00098178	Inferred_automatically	RNAi_primary
			WBRNAi00017294	Inferred_automatically	RNAi_primary
			WBRNAi00026008	Inferred_automatically	RNAi_primary
			WBRNAi00110318	Inferred_automatically	RNAi_primary
			WBRNAi00077520	Inferred_automatically	RNAi_primary
			WBRNAi00026009	Inferred_automatically	RNAi_primary
			WBRNAi00051096	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr8777
			Expr9209
			Expr9943
			Expr9944
			Expr15868
			Expr1011544
			Expr1030184
			Expr1154803
			Expr2009698
			Expr2027937
		Drives_construct	WBCnstr00013515
			WBCnstr00013798
			WBCnstr00014952
			WBCnstr00014953
			WBCnstr00015746
			WBCnstr00015747
			WBCnstr00015748
			WBCnstr00015749
			WBCnstr00037607
		Construct_product	WBCnstr00015747
			WBCnstr00015748
			WBCnstr00015749
			WBCnstr00037607
		Microarray_results (28)
		Expression_cluster	WBPaper00024375:Up_N2_vs_vhl-1
			WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00032425:down_in_rde-4
			WBPaper00032528:L3_enriched
			WBPaper00032976:dosage_compensated_genes
			WBPaper00033065:cyc-1(RNAi)_upregulated
			WBPaper00035269:cde-1_regulated
			WBPaper00037946:MAB-5_interacting
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:all-neurons_L2-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:coelomocytes_L2-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:excretory-cell_larva_enriched
			WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
			WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:germline-precursors_embryo_enriched
			WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
			WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:pharyngeal-muscle_embryo_enriched
			WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038104:DATS_upregulated
			WBPaper00038118:aak-2(gt33)_upregulated
			WBPaper00038237:age-1_upregulated_intestine_rescue
			WBPaper00038237:age-1_upregulated_neuron_rescue
			WBPaper00038237:age-1_upregulated_nontransgenic
			WBPaper00040990:PA14_upregulated
			WBPaper00044260:1-methylnicotinamide_downregulated
			WBPaper00044316:CH3HgCl_2.0uM_downregulated
			WBPaper00044316:CH3HgCl_7.5uM_downregulated
			WBPaper00044426:rotenone_24h_upregulated
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044656:tatn-1(qd182)_upregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
			WBPaper00045314:S.aureus-induced_N2
			WBPaper00045521:Gender_Neutral
			WBPaper00045571:germline-ablation_upregulated
			WBPaper00045774:clk-1_upregulated
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
			WBPaper00046497:B.thuringiensis_upregulated_protein
			WBPaper00046741:Garlic-Extract_upregulated_mRNA
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00048923:Aging_regulated
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00048988:neuron_expressed
			WBPaper00049217:TCER-1_downregulated
			WBPaper00049290:rsks-1(sv31)_downregulated
			WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
			WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
			WBPaper00049920:Glucose-Diet_upregulated_N2
			WBPaper00049942:HeatShock_upregulated_hsf-1(+)
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050332:skn-1(RNAi)_downregulated
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
			WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
			WBPaper00050488:20C_vs_25C_regulated_N2_adult
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
			WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00050990:pharynx_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051245:epidermis_cytoplasm_expressed
			WBPaper00051245:epidermis_nucleus_expressed
			WBPaper00051245:intestine_cytoplasm_expressed
			WBPaper00051245:intestine_nucleus_expressed
			WBPaper00051245:nucleus_specific
			WBPaper00051352:Long-Term-Association-Memory_downregulated
			WBPaper00051388:Glucose-diet_downregulated
			WBPaper00051558:aging_regulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053599:female_vs_male_downregulated
			WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
			WBPaper00053771:up_at_24h-NaCl
			WBPaper00053771:up_at_dpy-7(e88)
			WBPaper00053810:daf-2(e1370)_upregulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00055354:Psora-Allantoin_downregulated
			WBPaper00055354:Psora_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Metformin_downregulated
			WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
			WBPaper00055354:Rifampicin-Psora_upregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00055482:pmt-2(RNAi)_upregulated
			WBPaper00055482:Tunicamycin_downregulated
			WBPaper00055626:pry-1(mu38)_downregulated
			WBPaper00055971:nhl-2(ok818)_25C_downregulated
			WBPaper00056034:pals-25(jy9)_downregulated
			WBPaper00056039:efa-6(tm3124)_downregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056090:E.faecalis_upregulated_N2
			WBPaper00056139:soil-microbiota_downregulated
			WBPaper00056139:soil-microbiota_upregulated
			WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
			WBPaper00056218:daf-16(mu86)_upregulated_Day3
			WBPaper00056290:hsp-6(mg585)_upregulated
			WBPaper00056290:mdt-15(mg584)_upregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00057041:unc-70(cas983)_downregulated
			WBPaper00057347:nhr-14(tm1473)_upreglated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058598:spn-4(tm291)_upregulated
			WBPaper00058691:sin-3(tm1276)_downregulated
			WBPaper00059471:EGL-43_interacting
			WBPaper00059529:nonu-1(srf0780)_upregulated
			WBPaper00059537:ngn-1(ok2200)_upregulated
			WBPaper00059566:wdr-23(mac32)_upregulated
			WBPaper00059605:MUT-16_interacting
			WBPaper00059895:wounding_downregulated
			WBPaper00060014:set-2(zr2012)_downregulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
			WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
			WBPaper00060459:bcat-1(RNAi)_upregulated
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060908:TEBP-1_interacting
			WBPaper00060908:TEBP-2_interacting
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00061081:E.faecalis_upregulated_N2
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061274:hypergravity_15xg_upregulated
			WBPaper00061340:AUA
			WBPaper00061340:AVD
			WBPaper00061340:RIA
			WBPaper00061340:RIB
			WBPaper00061340:RMD
			WBPaper00061340:SMD
			WBPaper00061340:URX
			WBPaper00061424:Diet_MYb120_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated
			WBPaper00061527:C18B2.5-haf-4_181
			WBPaper00061651:ADF_enriched
			WBPaper00061651:AIN_enriched
			WBPaper00061651:AIZ_enriched
			WBPaper00061651:AUA_enriched
			WBPaper00061651:Excretory_cell_enriched
			WBPaper00061651:PQR_enriched
			WBPaper00061651:RIB_enriched
			WBPaper00061651:RIH_enriched
			WBPaper00061651:RIR_enriched
			WBPaper00061651:URX_enriched
			WBPaper00061753:csr-1(tor159)_downregulated_20C
			WBPaper00061818:ELKS-1_interacting
			WBPaper00061902:camt-1(ok515)_regulated_RMG
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062193:skn-1(RNAi)_upregulated
			WBPaper00062237:dnj-21(RNAi)_downregulated_protein
			WBPaper00062345:bortezomib_4h_downregulated_N2
			WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
			WBPaper00062498:PPM-1.D_interacting
			WBPaper00062520:qui-1(db104)_upregulated
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064005:starvation_downregulated_N2_mRNA
			WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
			WBPaper00064055:trl-1(cas1077)_downregulated_starved
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
			WBPaper00064637:cox-5B(RNAi)_upregulated
			WBPaper00064716:paraquat_downregulated
			WBPaper00064727:daf-2(e1370)_upregulated
			WBPaper00064992:Capsaicin_downregulated
			WBPaper00065288:mdt-15(tm2182)_downregulated
			WBPaper00065373:Cisplatin_upregulated_WT
			WBPaper00065373:sek-1(km4)_upregulated_Ref
			WBPaper00065578:gcn-1(nc40)_downregulated
			WBPaper00065835:Day11_vs_Day1_downregulated
			WBPaper00065841:79_1
			WBPaper00065841:79_2
			WBPaper00065841:121_0
			WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
			WBPaper00066232:ash-2(RNAi)_downregulated_WT
			cgc4386_cluster_1_4
			cgc4489_group_25
			WBPaper00024393:strongly_regulated_dauer_genes
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026629:L3_male_enriched
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00031252:AIN-1_IP_enriched
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00031832:slr-2_regulated
			WBPaper00031850:mdt-15(RNAi)_downregulated
			WBPaper00032062:age_regulated_genes
			WBPaper00032948:StarveUp2
			WBPaper00034739:TreatmentAffectedGenes
			WBPaper00036123:Atrazine_regulated
			WBPaper00036130:mir-243_up_regulated
			WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
			WBPaper00040210:Chlorpyrifos_16C_regulated
			WBPaper00041002:HF_3d_2.0mM_Up
			WBPaper00041002:HF_11d_2.0mM_Up
			WBPaper00041211:RPW-24_Up
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_EtBr-exposed_24h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
			WBPaper00042128:gei-8(ok1671)_upregulated
			WBPaper00042178:hlh-29(tm284)_upregulated
			WBPaper00042274:tbx-2(bx59)_upregulated
			WBPaper00042331:a-SWCNTs_downregulated
			WBPaper00047070:N2_starvation_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
			WBPaper00048989:N2_allantoin_downregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00053236:Starvation_regulated_N2
			WBPaper00053550:daf-19(m86)_upregulated_L1
			WBPaper00057098:SiO2-nanoparticles_downregulated
		Interaction (16)
	Map_info	Map	X	Position	12.7093	Error	0.004543
		Positive	Positive_clone	R01E6	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (11)
	Remark	Sequence connection from [Hewett-Emmett D]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene