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WormBase Tree Display for Gene: WBGene00001006

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Name Class

WBGene00001006EvidenceCGC_data_submission
SMapS_parentSequenceC25F6
IdentityVersion1
NameCGC_namedlg-1
Sequence_nameC25F6.2
Molecular_nameC25F6.2
C25F6.2.1
CE36524
Other_nameCELE_C25F6.2Accession_evidenceNDBBX284606
Public_namedlg-1
DB_infoDatabaseAceViewgeneXG103
WormQTLgeneWBGene00001006
WormFluxgeneWBGene00001006
NDBlocus_tagCELE_C25F6.2
PanthergeneCAEEL|WormBase=WBGene00001006|UniProtKB=G5ECY0
familyPTHR23119
NCBIgene180819
RefSeqproteinNM_001029260.5
SwissProtUniProtAccG5ECY0
UniProt_GCRPUniProtAccG5ECY0
OMIMgene300189
602887
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdlg
Allele (112)
Possibly_affected_byWBVar02153212
StrainWBStrain00007529
WBStrain00033917
WBStrain00024324
WBStrain00026592
RNASeq_FPKM (74)
GO_annotation (35)
Ortholog (51)
ParalogWBGene00011890Caenorhabditis elegansFrom_analysisPanther
WBGene00017741Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptiondlg-1 encodes a MAGUK protein, orthologous to Drosophila Discs large; DLG-1 is physically located at apical adherens junctions in all epithelia and is required for organization of the embryonic gut epithelium into a coherent tube.Paper_evidenceWBPaper00004424
WBPaper00004510
WBPaper00006400
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated27 Jan 2012 00:00:00
Automated_descriptionPredicted to enable guanylate kinase activity. Involved in embryo development and zonula adherens assembly. Located in adherens junction and apical junction complex. Expressed in several structures, including arcade cell; germ line; intestine; pharyngeal cell; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; cervix uteri carcinoma in situ; intellectual disability (multiple); and invasive ductal carcinoma. Is an ortholog of human DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060307Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2903)
DOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2903)
DOID:8991Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2900)
DOID:3008Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2900)
DOID:0112041Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2902)
Molecular_infoCorresponding_CDSC25F6.2
Corresponding_CDS_historyC25F6.2a:wp121
C25F6.2b:wp271
Corresponding_transcriptC25F6.2.1
Other_sequence (86)
Associated_feature (29)
Experimental_infoRNAi_result (34)
Expr_pattern (15)
Drives_construct (17)
Construct_productWBCnstr00000944
WBCnstr00006155
WBCnstr00007873
WBCnstr00010311
WBCnstr00010468
WBCnstr00015686
WBCnstr00020203
WBCnstr00020897
WBCnstr00037145
WBCnstr00042006
AntibodyWBAntibody00000342
WBAntibody00000426
WBAntibody00000715
WBAntibody00000716
WBAntibody00000993
WBAntibody00001401
WBAntibody00001716
WBAntibody00001732
WBAntibody00002172
WBAntibody00002424
Microarray_results (27)
Expression_clusterWBPaper00032976:dosage_compensated_genes
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033070:Elbe_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040209:B.thuringiensis_upregulated_MY15
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_upregulated_Day5
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00044760:somatic_specific
WBPaper00045521:Oogenic
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045774:clk-1_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:HMG-4_interacting_protein
WBPaper00055049:S.gordonii_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055648:male-vas-deferens_expressed
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:ptl-1(ok621)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056284:ints-11(RNAi)_downregulated
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060764:swsn-1(os22ts)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_upregulated
WBPaper00061340:F_U
WBPaper00061340:G2_and_W_blasts
WBPaper00061340:Glia
WBPaper00061340:hyp4_hyp5_hyp6
WBPaper00061340:K_Kprime
WBPaper00061340:mc3
WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
WBPaper00061340:Parent_of_AMsh_URB
WBPaper00061340:Parent_of_PVP_and_rect_V
WBPaper00061340:P_cell
WBPaper00061340:T
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061527:chd-7_16664-jmjd-3.1
WBPaper00061527:ldb-1_2877-scd-1_3086
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062237:dnj-21(RNAi)_upregulated_protein
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064201:SNA-3_interacting
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065158:25C_vs_15C_upregulated_AFD
WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
WBPaper00065841:5_1
WBPaper00065841:11_2
WBPaper00065841:56_0
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4386_cluster_6_3
cgc4489_group_24
WBPaper00005475:Aging-regulated
WBPaper00025032:cluster_129
WBPaper00025141:N2_Expressed_Genes
WBPaper00029437:dcr-1_upregulated
WBPaper00029437:rde-1_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00031832:slr-2_regulated
WBPaper00034661:AgNPs_downregulated
WBPaper00034757:up_by_oxidative_stress
WBPaper00036464:S.aureus-RN6390_regulated
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00038060:SUMO-1_downregulated
WBPaper00038304:octr-1_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040821:Au-NP_regulated
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00045673:colistin_upregulated
WBPaper00046639:tyrosol_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00050767:Octopamine_induced
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_12
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(143_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
Interaction (1194)
Map_infoMapXPosition-5.25173Error0.010511
PositivePositive_cloneC25F6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4261
4449
Pseudo_map_position
ReferenceWBPaper00004510
WBPaper00004765
WBPaper00004780
WBPaper00004961
WBPaper00004964
WBPaper00005372
WBPaper00005576
WBPaper00005969
WBPaper00005975
WBPaper00006196
WBPaper00006400
WBPaper00006422
WBPaper00006462
WBPaper00006463
WBPaper00011311
WBPaper00011601
WBPaper00012331
WBPaper00013425
WBPaper00016966
WBPaper00017617
WBPaper00017731
WBPaper00017732
WBPaper00017733
WBPaper00017734
WBPaper00018116
WBPaper00018120
WBPaper00018122
WBPaper00019574
WBPaper00019576
WBPaper00024200
WBPaper00024261
WBPaper00024738
WBPaper00024816
WBPaper00024817
WBPaper00027155
WBPaper00027244
WBPaper00027245
WBPaper00027414
WBPaper00029033
WBPaper00029128
WBPaper00030521
WBPaper00030629
WBPaper00031185
WBPaper00031697
WBPaper00032108
WBPaper00032115
WBPaper00032233
WBPaper00032467
WBPaper00033350
WBPaper00035600
WBPaper00036023
WBPaper00036179
WBPaper00036205
WBPaper00036843
WBPaper00036871
WBPaper00036979
WBPaper00037766
WBPaper00038491
WBPaper00038628
WBPaper00038669
WBPaper00039779
WBPaper00039809
WBPaper00040999
WBPaper00042762
WBPaper00042878
WBPaper00045462
WBPaper00046645
WBPaper00049111
WBPaper00050170
WBPaper00051293
WBPaper00051878
WBPaper00052187
WBPaper00053439
WBPaper00055090
WBPaper00056223
WBPaper00056902
WBPaper00056919
WBPaper00057738
WBPaper00057739
WBPaper00058130
WBPaper00058724
WBPaper00059330
WBPaper00059613
WBPaper00060754
WBPaper00060787
WBPaper00060888
WBPaper00062058
WBPaper00062161
WBPaper00062248
WBPaper00063007
WBPaper00063074
WBPaper00064105
WBPaper00064182
WBPaper00064587
WBPaper00064685
WBPaper00064911
WBPaper00065282
RemarkSequence connection from [Bossinger O]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene