| WBGene00000380 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cct-5 | Person_evidence | WBPerson89 |
| | | Sequence_name | C07G2.3 |
| | | Molecular_name | C07G2.3 |
| | | | C07G2.3.1 |
| | | | CE02985 |
| | | Other_name | CELE_C07G2.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | cct-5 |
| | DB_info | Database | AceView | gene | 3F590 |
| | | | WormQTL | gene | WBGene00000380 |
| | | | WormFlux | gene | WBGene00000380 |
| | | | NDB | locus_tag | CELE_C07G2.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000380|UniProtKB=P47209 |
| | | | | family | PTHR11353 |
| | | | NCBI | gene | 175588 |
| | | | RefSeq | protein | NM_171104.7 |
| | | | SwissProt | UniProtAcc | P47209 |
| | | | UniProt_GCRP | UniProtAcc | P47209 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cct |
| | Allele (109) |
| | Legacy_information | [C.elegansII] NMK. Encodes one of 7-9 related subunits of eukaryotic cytosolic chaperonin CCT. Ortholog of mouse Ccte (68% aa sequence identity)[PC] |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Contained_in_operon | CEOP3192 |
| | Ortholog | WBGene00037548 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00157961 | Caenorhabditis brenneri | From_analysis | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00123838 | Caenorhabditis japonica | From_analysis | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00061767 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00233964 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g5844 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g8470 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g9113 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g9892 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP31.g24051 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP32.g3448 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g2432 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g1545 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g18626 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cni-cct-5 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold544.g3432 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00315.g9269 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | GCK72_010087 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g05072 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g20464 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_30073010 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrIII_pilon.g7466 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00244486 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00109348 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | | WBGene00261999 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | WBGene00299853 | Trichuris muris | From_analysis | WormBase-Compara |
| | | SGD:S000003825 | Saccharomyces cerevisiae | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | FB:FBgn0010621 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-030131-977 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:1618 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:107185 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:735161 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | Paralog | WBGene00000377 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000378 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000379 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00020391 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00021934 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000381 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00018782 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002025 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00004089 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | cct-5 encodes, by alternative splicing, two isoforms of a putative epsilon subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human CCT5 (OMIM:610150, mutated in sensory neuropathy with spastic paraplegia); CCT-5 represses SKN-1-dependent transcription of gst-4; in mass RNAi assays, cct-5 is required for normal embryonic osmotic integrity, transgene subcellular localization, viability (throughout the life cycle), fertility, vulval development, and locomotion. | Paper_evidence (11) |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 14 Jan 2008 00:00:00 |
| | | Automated_description | Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Part of chaperonin-containing T-complex. Is an ortholog of human CCT5 (chaperonin containing TCP1 subunit 5). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C07G2.3 |
| | Corresponding_CDS_history | C07G2.3:wp67 |
| | | C07G2.3b:wp275 |
| | Corresponding_transcript | C07G2.3.1 |
| | Other_sequence (202) |
| | Associated_feature (25) |
| Experimental_info | RNAi_result (32) |
| | Expr_pattern | Expr1017478 |
| | | Expr1030206 |
| | | Expr1144097 |
| | | Expr2009773 |
| | | Expr2028013 |
| | Drives_construct | WBCnstr00037583 |
| | Construct_product | WBCnstr00037583 |
| | Antibody | WBAntibody00000158 |
| | | WBAntibody00002551 |
| | Microarray_results (34) |
| | Expression_cluster | WBPaper00026640:Development_Group_I |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035926:A.hydrophila_regulated |
| | | WBPaper00035963:S.aureus_1h_downregulated |
| | | WBPaper00035963:S.aureus_4h_downregulated |
| | | WBPaper00035963:S.aureus_8h_downregulated |
| | | WBPaper00035963:S.aureus_24h_downregulated |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049177:rpn-10(ok1865)_upregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050199:hsf-1(ok600)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052987:UV_downregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053254:hsp-90(RNAi)_upregulated_protein |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_protein |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059254:PRG-1_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:PLM |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00061527:tars-1-AFFX-r2-3026-5_at |
| | | WBPaper00061651:AFD_enriched |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_downregulated |
| | | WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00037113:CPF_16C_down-regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042234:xpa-1_upregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (101) |
| | Anatomy_function | WBbtf0414 |
| Map_info | Map | III | Position | -3.14573 | Error | 0.001936 |
| | Positive | Positive_clone | C07G2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (19) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
